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BEACOPP

肿瘤

关键词肿瘤 治疗方法 霍奇金淋巴瘤

词汇介绍

拓展阅读

解析

Bleomycin   /,bliə'maɪsɪn/

释    义   n. [药] 争光霉素,[微][药] 博来霉素

例    句   DNA single-strand, breakage following Bleomycin treatment of P388 cells was studied by the method in vitro. 应用体外实验方法对博来霉素引起P388白血病细胞DNA单链断裂效应进行了探讨。


Etoposide 

释    义   n. 依托泊苷

例    句   To investigate the effect of Etoposide alone maintenance chemotherapy for small cell lung cancer (SCLC). 探讨依托泊苷单药维持化疗对小细胞肺癌的疗效及对生活质量的影响。


Doxorubicin   /,dɑksə'rʊbɪsɪn/

释    义   n. 阿霉素;亚德里亚霉素

例    句   This translates into enhanced therapeutic efficacy for drugs like doxorubicin that have intracellular site of action. 继而又转化成提高阿霉素这类作用于细胞内位点药物的治疗效果。


Cyclophosphamide   /,saɪklə'fɑsfə,maɪd/

释    义   n. [药] 环磷酰胺

例    句   Treatment with immunosuppressants such as rituximab, azathioprine and cyclophosphamide resulted in a marked reduction in antibody levels and relapse rates. 免疫抑制剂治疗,如利妥昔单抗,硫唑嘌呤和环磷酰胺,明显减少抗体水平和复发率。


Vincristine   英 /vɪn'krɪstiːn/   美 /vɪn'krɪs,tin/

释    义   n. [药] 长春新碱(一种抗肿瘤药)

例    句   Asiaticoside, as a biochemical modulator, may induce apoptosis, and enhance anti tumor activity of vincristine in cancer cells, might be useful in cancer chemotherapy. 积雪草甙可诱导肿瘤细胞凋亡,并与长春新碱显示协同作用,有可能作为生化调节剂应用于肿瘤化。


Procarbazine   /prəu'kɑ:bəzi:n, -zin/

释    义   n. 甲基苄肼;甲苄肼(一种抗肿瘤药)

例    句   Procarbazine, nitrogen mustard, and ifosfamide, which can increase risk for myelodysplastic syndromes and acute myelogenous leukemia. 丙卡巴肼、氮芥和异环磷酰胺:可增加患骨髓增生异常综合症和急性粒细胞白血病的风险。


Prednisone   英 /'prednɪzəʊn/   美 /'prɛdnɪzon/

释    义   n. [药] 泼尼松(肾上腺皮质激素),

例    句   Without adrenal function, eat prednisone what to side effect there is? 没有肾上腺功能,吃泼尼松有哪些副作用?

概述

BEACOPP化疗方案(Bleomycin+ etoposide+ doxorubicin+ cyclophosphamide+ vincristine+ procarbazine+ prednisone),即:博来霉素+依托泊苷+阿霉素+环磷酰胺+长春新碱+甲基苄肼+泼尼松。   霍奇金淋巴瘤(Hodgkin lymphoma , HL)是起源于淋巴造血组织的恶性肿瘤。在我国,HL的发病率不似欧美国家之高,但该病却是最早可被治愈的肿瘤之一

Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma复制标题

早期或晚期霍奇金淋巴瘤患者一线化疗 (包括beaopp升级) 与化疗 (包括ABVD) 的比较

发表时间:2017-05-25

影响因子:7.8

作者: Nicole Skoetz

期刊:Cochrane Database Syst Rev

BACKGROUND: There are two different international standards for the treatment of early  unfavourable and advanced stage Hodgkin lymphoma (HL): chemotherapy with escalated BEACOPP (bleomycin/etoposide/doxorubicin/cyclophosphamide/vincristine/procarbazine/prednisone) regimen and chemotherapy with ABVD (doxorubicin/bleomycin/vinblastine/dacarbazine) regimen. OBJECTIVES: To determine the advantages and disadvantages of chemotherapy including escalated BEACOPP compared to chemotherapy including ABVD in the treatment of early unfavourable or advanced stage HL as first-line treatment. SEARCH METHODS: We searched for randomised controlled trials in MEDLINE, CENTRAL and conference proceedings (January 1985 to July 2013 and for the update to March 2017) and Embase (1985 to November 2008). Moreover we searched trial  registries (March 2017; www.controlled-trials.com, www.clinicaltrialsregister.eu/ctr-search/search, clinicaltrials.gov, www.eortc.be, www.ghsg.org, www.ctc.usyd.edu.au, www.trialscentral.org/index.html) SELECTION CRITERIA: We included randomised controlled trials examining chemotherapy including at least two cycles of escalated BEACOPP regimens compared with chemotherapy including at least four cycles of ABVD regimens as first-line treatment for patients with early unfavourable stage or advanced stage HL.

译文

背景:早期恶性和晚期霍奇金淋巴瘤(HL)的治疗有两种不同的国际标准:BEACOPP(博莱霉素/依托泊苷/阿霉素/环磷酰胺/长春新碱/原卡巴津/强的松)方案和ABVD(阿霉素/博莱霉素/长春碱/达卡巴津)方案养生。 目的:探讨以BEACOPP为主的化疗方案与ABVD为主的化疗方案在治疗早期或晚期HL中的优缺点。 搜索方法:我们在MEDLINE、CENTRAL和conference程序(1985年1月至2013年7月和2017年3月的更新)和Embase(1985年至2008年11月)中搜索随机对照试验。此外,我们还搜索了试验登记处(2017年3月;www.controlled-trials.com,www.clinicaltrialsregister.eu/ctr-search/search,clinicaltrials.gov,www.eortc.be,www.ghsg.org,www.ctc.usyd.edu.au,www.trialscentral.org/index.html)选择标准:我们包括随机对照试验,检查化疗,包括至少两个周期的BEACOPP方案,与化疗相比,包括至少四个周期的ABVD方案,作为早期不利阶段或晚期HL患者的一线治疗。