肿瘤
词汇介绍
拓展阅读
解析
Bleomycin /,bliə'maɪsɪn/
释 义 n. [药] 争光霉素,[微][药] 博来霉素
例 句 DNA single-strand, breakage following Bleomycin treatment of P388 cells was studied by the method in vitro. 应用体外实验方法对博来霉素引起P388白血病细胞DNA单链断裂效应进行了探讨。
Etoposide
释 义 n. 依托泊苷
例 句 To investigate the effect of Etoposide alone maintenance chemotherapy for small cell lung cancer (SCLC). 探讨依托泊苷单药维持化疗对小细胞肺癌的疗效及对生活质量的影响。
Doxorubicin /,dɑksə'rʊbɪsɪn/
释 义 n. 阿霉素;亚德里亚霉素
例 句 This translates into enhanced therapeutic efficacy for drugs like doxorubicin that have intracellular site of action. 继而又转化成提高阿霉素这类作用于细胞内位点药物的治疗效果。
Cyclophosphamide /,saɪklə'fɑsfə,maɪd/
释 义 n. [药] 环磷酰胺
例 句 Treatment with immunosuppressants such as rituximab, azathioprine and cyclophosphamide resulted in a marked reduction in antibody levels and relapse rates. 免疫抑制剂治疗,如利妥昔单抗,硫唑嘌呤和环磷酰胺,明显减少抗体水平和复发率。
Vincristine 英 /vɪn'krɪstiːn/ 美 /vɪn'krɪs,tin/
释 义 n. [药] 长春新碱(一种抗肿瘤药)
例 句 Asiaticoside, as a biochemical modulator, may induce apoptosis, and enhance anti tumor activity of vincristine in cancer cells, might be useful in cancer chemotherapy. 积雪草甙可诱导肿瘤细胞凋亡,并与长春新碱显示协同作用,有可能作为生化调节剂应用于肿瘤化。
Procarbazine /prəu'kɑ:bəzi:n, -zin/
释 义 n. 甲基苄肼;甲苄肼(一种抗肿瘤药)
例 句 Procarbazine, nitrogen mustard, and ifosfamide, which can increase risk for myelodysplastic syndromes and acute myelogenous leukemia. 丙卡巴肼、氮芥和异环磷酰胺:可增加患骨髓增生异常综合症和急性粒细胞白血病的风险。
Prednisone 英 /'prednɪzəʊn/ 美 /'prɛdnɪzon/
释 义 n. [药] 泼尼松(肾上腺皮质激素),
例 句 Without adrenal function, eat prednisone what to side effect there is? 没有肾上腺功能,吃泼尼松有哪些副作用?
概述
概述
BEACOPP化疗方案(Bleomycin+ etoposide+ doxorubicin+ cyclophosphamide+ vincristine+ procarbazine+ prednisone),即:博来霉素+依托泊苷+阿霉素+环磷酰胺+长春新碱+甲基苄肼+泼尼松。
霍奇金淋巴瘤(Hodgkin lymphoma , HL)是起源于淋巴造血组织的恶性肿瘤。在我国,HL的发病率不似欧美国家之高,但该病却是最早可被治愈的肿瘤之一,并被视为药物治疗恶性肿瘤之典范。
霍奇金淋巴瘤主要是一种年轻人的癌症,发生于35岁的中位年龄。HL是治疗效果较好、治愈率较高的恶性肿瘤,随着放疗技术和化疗药物优化组合,尤其是化放疗综合治疗的应用,早期HL的10年总生存率已接近90%,患者可获得长期生存。对于晚期HL即m/W期或具有不良预后因素的nB期患者,对这种情况的全身治疗已经从以基于烷化剂的化疗方案发展到目前使用的阿霉素、博莱霉素、长春花碱和达卡巴嗪(ABVD)治疗,目前认为以化疗为主的综合治疗,特别是ABVD方案仍然是标准方案。
近年来应用BEACOPP方案和Standford V、CEC方案等,也备受关注。针对HL的化疗研究表明,化疗药物的剂量强度与晚期HL的治疗疗效存在相关性,故1990年德国霍奇金协作小组制定了BEACOPP方案,并在系列的n / m期临床试验中证实了该方案的良好疗效。越来越多的证据表明,加强治疗可使复发风险较高的患者受益,一些临床医生提倡对晚期或高危早期疾病患者使用BEACOPP治疗。BEACOPP方案又可分为常规剂量组和增强剂量组,后者的毒副反应特别是骨髓抑制也引起人们的关注。
用药方法
博来霉素10 mg/m2,在第8天静脉注射给药。依托泊苷100(200*) mg/m2 第1至3天通过静脉注射给药。多柔吡星(阿霉素)25(35*) mg/m2,第1天静脉注射给药。环磷酰胺650(1250*) mg/m2,第1天静脉注射给药。长春新碱1.4 mg/m2,第8天静脉注射给药。甲基苄肼100 mg/m2,第1至7天口服。泼尼松40 mg/m2,第1至14天口服。
优势
在一项多中心、前瞻性、随机对照临床试验中进行一线方案选择ABVD和BEACOPP的差异对比。研究共纳入331名患者,随机分为两组,分别接受6-8 周期的ABVD方案和4个周期增强剂量联合4个标准剂量BEACOPP方案治疗。
结果发现,BEACOPP组7年无首次进展率为85%,而ABVD组为73%相差12%。ABVD组107名患者(64%)及BEACOPP 组114名患者(70%)初始化疗结束后达到完全缓解。通过各项数据综合分析表明,BEACOPP方案较ABVD方案有较好的初始治疗肿瘤控制率,但长期临床结局两组无差异。
早期或晚期霍奇金淋巴瘤患者一线化疗 (包括beaopp升级) 与化疗 (包括ABVD) 的比较
发表时间:2017-05-25
影响指数:7.8
作者: Nicole Skoetz
期刊:Cochrane Database Syst Rev
BACKGROUND: There are two different international standards for the treatment of early unfavourable and advanced stage Hodgkin lymphoma (HL): chemotherapy with escalated BEACOPP (bleomycin/etoposide/doxorubicin/cyclophosphamide/vincristine/procarbazine/prednisone) regimen and chemotherapy with ABVD (doxorubicin/bleomycin/vinblastine/dacarbazine) regimen. OBJECTIVES: To determine the advantages and disadvantages of chemotherapy including escalated BEACOPP compared to chemotherapy including ABVD in the treatment of early unfavourable or advanced stage HL as first-line treatment. SEARCH METHODS: We searched for randomised controlled trials in MEDLINE, CENTRAL and conference proceedings (January 1985 to July 2013 and for the update to March 2017) and Embase (1985 to November 2008). Moreover we searched trial registries (March 2017; www.controlled-trials.com, www.clinicaltrialsregister.eu/ctr-search/search, clinicaltrials.gov, www.eortc.be, www.ghsg.org, www.ctc.usyd.edu.au, www.trialscentral.org/index.html) SELECTION CRITERIA: We included randomised controlled trials examining chemotherapy including at least two cycles of escalated BEACOPP regimens compared with chemotherapy including at least four cycles of ABVD regimens as first-line treatment for patients with early unfavourable stage or advanced stage HL.
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