释 义 adj. 肝细胞的
例 句 Expression of MT1E during the formation of hepatocellular carcinoma and its function in hepatocarcinoma cells. MT1E在肝癌形成过程中的表达及其在肝癌细胞中的作用。
Carcinoma 英 /ˌkɑːsɪˈnəʊmə/ 美 /ˌkɑːrsɪˈnoʊmə/
释 义 n. [肿瘤] 癌
例 句 You may see undifferentiated carcinoma of the oesophagus' in your medical reports if you have this type of oesophageal cancer. 如果您有这种食道癌，在您的医疗报告中就会看到这种食道中未分化的癌。
释 义 n. 航模型式
例 句 How do I handle models that should have one and only one row in their database? 如何处理数据库中只有一行的模型?
作者： Renuka V. Iyer
The multikinase inhibitor sorafenib is the only standard first-line therapy for hepatocellular carcinoma (HCC). Here, we report the dose-dependent effects of sorafenib on the immune response, which is related to nuclear factor of activated T cells 1 (NFAT1) activity. In vitro and in vivo experiments were performed with low and high doses of sorafenib using human T cells and spontaneous developed woodchuck HCC models. In vitro studies demonstrated that following exposure to a high dose of sorafenib the baseline activity of NFAT1 in T cells was significantly increased. In a parallel event, high dose sorafenib resulted in a significant decrease in T cell proliferation and increased the proportion of PD-1 expressing CD8+ T cells with NFAT1 activation. In the in vivo model, smaller tumors were detected in the low-dose sorafenib treated group compared to the placebo and high-dose treated groups. The low-dose sorafenib group showed a significant tumor growth delay with significantly more CD3+ cells in tumor. This study demonstrates that sorafenib has immunomodulatory effects in a dose- and time-dependent manner. Higher dose of sorafenib treatment was associated with immunosuppressive action. This observed effect of sorafenib should be taken into consideration in the selection of optimum starting dose for future trials.