首页 > 肿瘤医学词汇大全 > Involved-field radiation therapy
Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children's Oncology Group phase I study.
Motexafin 钆和相关野放射治疗儿童内在脑桥胶质瘤: 一项儿童肿瘤组 I 期研究。

摘要

The purpose of this study was to determine the dose-limiting toxicities, maximum tolerated dose, pharmacokinetics, and intratumor and brain distribution of motexafin gadolinium (MGd) with involved field radiation therapy in children with newly diagnosed intrinsic pontine gliomas. MGd was administered as a 5-min intravenous bolus 2-5 h prior to standard radiation. The starting dose was 1.7 mg/kg. After first establishing that 5 doses/week for 6 weeks was tolerable, the dose of MGd was escalated until dose-limiting toxicity was reached. Radiation therapy was administered to 54 Gy in 30 once-daily fractions. Forty-four children received MGd at doses of 1.7 to 9.2 mg/kg daily prior to radiation therapy for 6 weeks. The maximum tolerated dose was 4.4 mg/kg. The primary dose-limiting toxicities were grade 3 and 4 hypertension and elevations in serum transaminases. Median elimination half-life and clearance values were 6.6 h and 25.4 ml/kg/h, respectively. The estimated median survival was 313 days (95% confidence interval, 248-389 days). The maximum tolerated dose of MGd and the recommended phase II dose was 4.4 mg/kg when administered as a daily intravenous bolus in conjunction with 6 weeks of involved field radiation therapy for pediatric intrinsic pontine gliomas.

译文

本研究的目的是确定运动毒素钆 (MGd) 的剂量限制毒性、最大耐受剂量、药代动力学以及肿瘤内和脑分布新诊断的内在脑桥胶质瘤儿童的介入放射治疗。在标准辐射前 2-5 小时,以 5 分钟静脉推注的方式给予 MGd。起始剂量为 1.7 毫克/千克。在首次确定持续 6 周的 5 剂/周可忍受后,MGd 的剂量增加,直到达到剂量限制性毒性。放射治疗给予 54 Gy,每天 30 次。44 名儿童在接受为期 6 周的放射治疗之前,每天接受 1.7 至 9.2 毫克/千克剂量的 MGd。最大耐受剂量为 4.4 mg/kg。主要的剂量限制毒性为 3 级和 4 级高血压和血清转氨酶升高。平均消除半衰期和清除值分别为 6.6 h 和 25.4毫升/kg/h。估计的中位生存期为 313 天 (95% 置信区间,248-389 天)。MGd 的最大耐受剂量和推荐的第二阶段剂量是 4.4 毫克/千克,当作为每日静脉推注与 6 周涉及的小儿内在脑桥胶质瘤的现场放射治疗一起给药时。

Involved-field radiation therapy

肿瘤 放射治疗 治疗方法
概述  :  

累及野(Involved Field):累及野范围包括临床上受累及的淋巴结区域,结外病变,如果没有淋巴结受累,累及野只包括受累器官的受累区域。以弥漫大B细胞淋巴瘤为例,累及野包括肿瘤床+病灶所在部位的淋巴引流区域。受累野局部放疗(IFRT)就是针对累及野进行放疗的方法,目前累及野放疗是淋巴瘤放疗的标准治疗手段。操作时大致是通过模拟机在人体表划定一个范围,放疗机发出射线,通过皮肤到达患者病变部位这个划定的范围,身体前后左右各个方向均可以。 应用结节性淋巴细胞为主型霍奇金淋巴瘤IA、I

Involved   英 /ɪnˈvɒlvd/   美 /ɪnˈvɑːlvd/

释    义   adj. 有关的;卷入的;复杂的

               v. 涉及;使参与;包含(involve的过去式和过去分词)

同根词   involute adj. [生物] 内卷的;纷乱的;错综复杂的

               involvement n. 牵连;包含;混乱;财政困难

               involute n. [数] 渐伸线

               involute vi. 恢复原状;消失

               involve vt. 包含;牵涉;使陷于;潜心于

例    句   It was an involved process, so he hired a professional to do it. 这是一道复杂的工序,因此他雇了一位专业人员来做。

 

Field   英 /fiːld/   美 /fiːld/

释    义   n. 领域;牧场;旷野;战场;运动场

               vi. 担任场外队员

               adj. 扫描场;田赛的;野生的

               vt. 把暴晒于场上;使上场

同根词   fielding n. 守备;防守

               fielder n. 外野手;外场员(等于fieldsman)

               fielding v. 保护;担任外场员(field的ing形式)

例    句   Do you have any experience in this field? 在这个领域你有工作经验吗?

 

Radiation   英 /ˌreɪdiˈeɪʃn/   美 /ˌreɪdiˈeɪʃn/

释    义   n. 辐射;放射物

同根词   radial adj. 半径的;放射状的;光线的;光线状的

               radiant adj. 辐射的;容光焕发的;光芒四射的

               radiate adj. 辐射状的,有射线的

               radioactive adj. [核] 放射性的;有辐射的

               radiating adj. [物] 辐射的

               radially adv. 放射状地

               radial n.射线,光线;

例    句   And then he analyzed the components of that radiation and this is what he found. 然后他分析了,这种辐射的组成部分,这就是他的发现。

 

Therapy   英 /ˈθerəpi/   美 /ˈθerəpi/

释    义   n. 治疗,疗法

例    句   This has application in both sales and therapy. 这在销售和治疗中都有应用。

请扫描右侧二维码,免费查看词汇专业知识背景