Nude 英 /njuːd/ 美 /nuːd/
释 义 adj. 裸的，裸体的；无装饰的；与生俱有的；n. 裸体；裸体画
例 句 The relevance of using nude mouse models for evaluating drug delivery to human tumors has recently been questioned by numerous researchers. 使用裸鼠模型评估药物给药对人类肿瘤的相关性最近受到许多研究人员的质疑。
Mice 英 /maɪs/ 美 /maɪs/
释 义 n. 老鼠（mouse的复数）
例 句 He has gathered evidence from mice to support this idea, but whether it is the case in people has yet to be tested. 他已经从老鼠实验中收集了支持这一观点的证据，但它对人是否也起作用还有待进一步测试。
作者： Janice García-Quiroz
Calcitriol is a multitarget anticancer hormone; however, its effects on angiogenesis remain contradictory. Herein, we tested whether the antiangiogenic phytochemicals curcumin or resveratrol improved calcitriol antitumorigenic effects in vivo. Triple-negative breast cancer tumoral cells (MBCDF-T) were xenografted in nude mice, maintaining treatments for 3 weeks. Tumor onset, volume and microvessel density were significantly reduced in mice coadministered with calcitriol and curcumin (Cal+Cur). Vessel count was also reduced in mice simultaneously treated with calcitriol and resveratrol (Cal+Rsv). Cal+Cur and Cal+Rsv treatments resulted in less tumor activated endothelium, as demonstrated by decreased tumor uptake of integrin-targeted biosensors in vivo. The renal gene expression of Cyp24a1 and Cyp27b1 suggested increased calcitriol bioactivity in the combined regimens. In vitro, the phytochemicals inhibited both MBCDF-T and endothelial cells proliferation, while potentiated calcitriol's ability to reduce MBCDF-T cell-growth and endothelial cells migration. Resveratrol induced endothelial cell death, as deduced by increased sub-G1 cells accumulation, explaining the reduced tumor vessel number in resveratrol-treated mice, which further diminished when combined with calcitriol. In conclusion, the concomitant administration of calcitriol with curcumin or resveratrol synergistically promoted anticancer effects in vitro and in vivo in human mammary tumor cells.