肿瘤
词汇介绍
拓展阅读
解析
Bevacizumab
释 义 n. 贝伐单抗
例 句 Causes of death were predominantly due to lung cancer, but 14 patients in the bevacizumab group and 2 in the control group died as a result of drug toxicity. 尽管导致患者死亡的原因主要是肺癌,但是贝伐单抗组的14名患者以及对照组的2名患者却死于药物毒性。
概述
Nivolumab治疗化疗耐药宫颈癌: 外阴炎作为一种新的免疫相关不良事件的报告和持续完全应答的分子分析
发表时间:2019-10-31
影响因子:8.7
作者: Florence Baettig
期刊:J Immunother Cancer
Treatment options for advanced cervical cancer are limited and patients experiencing recurrence after first-line cisplatin-based chemotherapy and bevacizumab have a poor prognosis. A recent phase II study in advanced cervical cancer has demonstrated a disease control rate of 68.4% with the immune checkpoint inhibitor nivolumab. By blocking immune checkpoints, immunotherapy puts the immune system into a state of hyper-activation that can cause immune-related adverse events. We present the clinical, pathological and molecular data of a patient with metastatic cervical cancer and progressive disease after second-line therapy. We report on the therapeutic response under third-line immunotherapy with nivolumab, the immune-related adverse events (IRAE), and their successful management.
译文