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首页 > 医学词汇大全 > Raltitrexed
Raltitrexed

肿瘤

关键词肿瘤 药物 肠癌

词汇介绍

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解析

Raltitrexed 

释    义   n. 雷替曲塞

例    句   Gel clot method of tachypleus amebocyte lysate(TAL) test was applied to detect bacterial endotoxins in Raltitrexed for injection. 应用凝胶凝块法检测注射用雷替曲塞中的细菌内毒素。

概述

雷替曲塞,商品名赛维健,活性成份为雷替曲塞,辅料是甘露醇、磷酸氢二钠及氢氧化钠。是白色或类白色疏松块状物或粉末。其化学名称:N-[5-[N-甲基-N-(2-甲基-4-氧代-3,4-二氢喹唑啉-6-甲基)氨基]2-噻吩甲酰基]-L-谷氨酸。分子式:C21H22N4O6S,分子量:458.49。 适应症在患者无法接受联合化疗时,本品可单药用于治疗不适合5-Fu/亚叶酸钙的晚期结直肠癌患者。 用法用量成人:推荐剂量为3毫克/平方米,用50-250毫升0.9%氯化钠注射液或5%葡

Enhanced electrochemical sensing of leukemia cells using drug/lipid co-immobilized on the conducting polymer layer复制标题

利用药物/脂质共固定在导电聚合物层上增强白血病细胞的电化学传感

发表时间:2016-12-15

影响因子:9.5

作者: N.G. Gurudatt

期刊:Biosens Bioelectron

Electrochemical biosensors using five anticancer drug and lipid molecules attached on the conducting polymer layer to obtain the orientation of drug molecules toward cancer cells, were evaluated as sensing materials and their performances were compared. Conjugation of the drug molecules with a lipid, phosphatidylcholine (PC) has enhanced the sensitivity towards leukemia cells and differentiates cancer cells from normal cells. The composition of each layer of sensor probe was confirmed by electrochemical and surface characterization experiments. Both impedance spectroscopy and voltammetry show the enhanced interaction of leukemia cells using the drug/lipid modified sensor probe. As the number of leukemia cells increased, the charge transfer resistance (Rct) in impedance spectra increased and the amine oxidation peak current of drug molecules in voltammograms decreased at around 0.7-1.0V. Of test drug molecules, raltitrexed (Rtx) showed the best performance for the cancer cells detection. Cancer and normal cell lines from different origins were examined to evaluate the degree of expression of folate receptors (FR) on cells surface, where cervical HeLa cell line was found to be shown the highest expression of the receptor.

译文

以5种抗癌药物和脂质分子附着在导电聚合物层上,获得药物分子对癌细胞的取向,作为传感材料,对它们的性能进行了比较。药物分子与脂质、磷脂酰胆碱(PC)的结合增强了对白血病细胞的敏感性,并将癌细胞与正常细胞区分开来。通过电化学和表面表征实验,确定了传感器探头各层的组成。阻抗谱和伏安法均表明药物/脂质修饰的传感器探针增强了白血病细胞的相互作用。随着白血病细胞数的增加,阻抗谱中的电荷转移电阻(RCT)增加,伏安图中药物分子的胺氧化峰电流降低约0.7~1.0V。试验药物分子中,雷替曲塞(RTX)显示出最佳的癌细胞检测性能。对不同来源的癌细胞和正常细胞株进行检测,以评估叶酸受体(FR)在细胞表面的表达程度,发现宫颈HeLa细胞株的叶酸受体表达最高。