微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Death associated protein kinase
Death associated protein kinase

肿瘤

关键词肿瘤 临床研究术语 DAPK

词汇介绍

拓展阅读

解析

Death /deθ/

释    义   n. 死亡;死神

同根词   dead adj. 无生命的;呆板的;废弃了的

               dying adj. 临终的,垂死的

               deadly adj. 致命的;非常的;死一般的

               deathly adj. 死一般的;致命的

               deathless adj. 不死的,不灭的

               deathlike adj. 象死人的;死了一样的

               dead adv. 完全地

               deadly adv. 非常;如死一般地

               deathly adv. 死了一样地;非常

               die n. 冲模,钢模;骰子;

例    句   How did you learn about his death ? 你是怎么知道他的死讯?

 

Associated   美 /əˈsoʊsieɪtɪd,əˈsoʊʃieɪtɪd/

释    义   adj. 关联的;联合的;v. 联系(associate的过去式和过去分词)

同根词   associate adj. 副的;联合的

               associative adj. 联想的;联合的;组合的

               associate n. 同事,伙伴;关联的事物

               association n. 协会,联盟,社团;联合;联想

               associationism n. 联想心理学;观念联合论

               associate vi. 交往;结交

               associate vt. 联想;使联合;使发生联系

例    句   Both responded, pointing out some of the problems associated with aid. 双方都做出了回应,指出了与援助有关的一些问题。

 

Kinase   英 /ˈkaɪneɪz/  美 /ˈkɪnneɪz/

释    义   n. [生化] 激酶;致活酶

例    句   More than 500 kinases have been identified, but we only have a half-dozen targeted kinase inhibitors. 现在已经发现了500多种激酶,但是我们只研制出六个靶向激酶抑制剂。

概述

死亡相关蛋白激酶(DAPK)是一种钙离子/钙调素调节的丝氨酸/苏氨酸蛋白激酶,于1995年由以色列的Kimchi等发现并命名,分子量为160 kD。DAPK含有多个功能区域,从N端到C端依次为激酶区、钙调素调节区、8个连续的锚蛋白重复序列、包含2个潜在核苷酸结合位点的ROC-COR区、1个死亡结构域与1个富含丝氨酸的尾巴。由于DAPK具有多功能区域,因此可受多个层次调节,如分子内信号、外源蛋白质以及写激酶和相互作用的磷酸酶。位于DAPK钙调素调节区的第308位的丝氨酸的自磷酸化可抑

Death-associated protein kinase (DAPK) family modulators: Current and future therapeutic outcomes复制标题

死亡相关蛋白激酶 (DAPK) 家族调节剂: 当前和未来的治疗结果

发表时间:2018-06-27

影响因子:9.8

作者: Ahmed Karam Farag PhD

期刊:Med Res Rev

Serine/threonine kinases (STKs) represent the majority of discovered kinases to date even though a few Food and Drug Administration approved STKs inhibitors are reported. The third millennium came with the discovery of an important group of STKs that reshaped our understanding of several biological signaling pathways. This family was named death-associated protein kinase family (DAPK family). DAPKs comprise five members (DAPK1, DAPK2, DAPK3, DRAK1, and DRAK2) and belong to the calcium/calmodulin-dependent kinases domain. As time goes on, the list of biological functions of this family is constantly updated. The most extensively studied member is DAPK1 (based on the publications number and Protein Data Bank reported crystal structures) that plays fundamental biological roles depending on the cellular context. DAPK1 regulates apoptosis, autophagy, contributes to the pathogenesis of Alzheimer's disease, acts as a tumor suppressor, inhibits metastasis, mediates the body responses to viral infections, and regulates the synaptic plasticity and depression. For their biological roles, several DAPKs' modulators have been reported for treatment of many diseases as well as acting as probe compounds to facilitate the understanding of the biological functions elicited by this family.

译文

丝氨酸/苏氨酸激酶(STKs)代表了迄今为止发现的大多数激酶,尽管已报道了一些获得美国食品和药物管理局批准的STKs抑制剂。第三个千年来临的是发现了一组重要的STK,从而重塑了我们对几种生物信号途径的理解。该家族被称为死亡相关蛋白激酶家族(DAPK家族)。 DAPK包含五个成员(DAPK1,DAPK2,DAPK3,DRAK1和DRAK2),并且属于钙/钙调蛋白依赖性激酶域。随着时间的流逝,该家族的生物学功能列表会不断更新。研究最广泛的成员是DAPK1(基于出版物号和Protein Data Bank报告的晶体结构),其根据细胞环境起着基本的生物学作用。 DAPK1调节细胞凋亡,自噬,促进阿尔茨海默氏病的发病机理,充当肿瘤抑制因子,抑制转移,介导人体对病毒感染的反应以及调节突触可塑性和抑制抑郁。由于其生物学作用,已报道了几种DAPK的调节剂可用于治疗许多疾病,并充当探针化合物以促进对这个家族引发的生物学功能的理解。