摘要

METHODS: A total of 180 patients with R/M SCCHN (1:1) were assigned to receive either cisplatin (40 mg/m2), docetaxel (40 mg/m2) and 5-FU (2000 mg/m2) at days 1 and 8 and cetuximab (400/250 mg/m2) at days 1, 8 and 15 (DPFC) or standard cisplatin (100 mg/m2) at day 1, 5-FU (1000 mg/m2) at days 1-4 and cetuximab (400/250 mg/m2) at days 1, 8 and 15 (PFC). Chemotherapy was repeated every 21 days and continued for a maximum of 6 cycles in absence of disease progression or limiting toxicity, followed by cetuximab maintenance (500 mg/m2 every 2 weeks). The primary end-point was progression-free survival (PFS). RESULTS: A preplanned interim analysis for toxicity after 20 patients/arm revealed excessive grade 3 and 4 gastrointestinal (65%) and infectious toxicities (35%) in arm A, which led to dose reduction of cisplatin to 30 mg/m2 and 5-FU to 1000 mg/m2 for subsequent patients. With a median follow-up of 2 years, grade 4 toxicities were 21.3% vs. 30.8% for DPFC and PFC, respectively. More treatment-related deaths occurred with DPFC vs. PFC, with 11.2% and 6.6%, respectively.

译文

方法:总共180例R / M SCCHN(1:1)患者在第1天接受顺铂(40 mg / m2),多西他赛(40 mg / m2)和5-FU(2000 mg / m2)治疗。第1天,第8天和第15天(DPFC)分别为8,西妥昔单抗(400/250 mg / m2)或第1天在第1天,第8天和标准顺铂(100 mg / m2)以及第1-4天的5-FU(1000 mg / m2)和在第1、8和15天(PFC)服用西妥昔单抗(400/250 mg / m2)。每隔21天重复进行一次化学疗法,在没有疾病进展或毒性受限的情况下,最多持续6个周期,然后维持西妥昔单抗(每2周500 mg / m2)。主要终点是无进展生存期(PFS)。结果:对20名患者/手臂的毒性进行了预先计划的中期分析,结果显示,A手臂的3级和4级胃肠道(65%)过高,感染毒性(35%),这导致顺铂的剂量降低至30 mg / m2和5-后续患者的FU至1000 mg / m2。中位随访期为2年,4级毒性分别为21.3%和DPFC和PFC的30.8%。与PFC相比,DPFC与治疗相关的死亡发生率更高,分别为11.2%和6.6%。

5-Fluorouracil

肿瘤 消化肿瘤 药物
概述  :  

5-氟尿嘧啶,通用名,氟尿嘧啶,化学名5-氟-2,4(1H,3H)-嘧啶二酮,简写为5-FU,分子式为C4H3FN2O2,分子量为130.08。本品为白色疏松块状物。规格是0.25 g,本品需先用适量注射用水溶解后使用。本品在体内经酶转变为5-氟尿嘧啶脱氧核苷,与胸腺嘧啶核苷合成酶的活性中心形成共价结合,使该酶的活性受到抑制,使胸腺嘧啶核苷生成减少,导致DNA的生物合成受阻;此外,它还可转变为三磷酸氟尿嘧啶核苷,以伪代谢物形式掺入RNA中,从而干扰RNA的正常生理功能,影响蛋白质的

5-Fluorouracil 

释    义   n. 5-氟尿嘧啶

例    句   She was given an electronic pump containing a four day dose of two chemotherapy drugs, 5-fluorouracil and cisplatin, to administer to herself at home. 医生给她开具了一种含有两种化疗药物(5-氟尿嘧啶和顺铂)四天剂量的电子泵给药装置,在家自我注射治疗。

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