微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > vincristine
vincristine

肿瘤

关键词肿瘤 药物 白血病

词汇介绍

拓展阅读

解析

Vincristine   英 /vɪn'krɪstiːn/   美 /vɪn'krɪs,tin/

释    义   n. [药] 长春新碱(一种抗肿瘤药)

例    句   The resistance cell line, ACC/VCR, was induced in the ACC cell line in vitro by progressive concentrations of vincristine (VCR), a drug of choice in the treatment of adenoid cystic carcinoma. 以长春新碱(VCR)为诱导剂,通过浓度递增间断刺激法对人腺样囊性癌细胞系(ACC)进行体外诱导耐药,建立耐VCR的腺样囊性癌细胞系ACC/VCR。

概述

长春新碱又称醛基长春碱,从夹竹桃科多年生亚灌木长春花的全草中提取的一种生物碱,是一种抗肿瘤植物药。长春花又名雁来红、日日新、四时春、三万花,是夹竹桃科植物长春花的全草,长春碱、长春新碱是长春花中具有抗肿瘤活性的二聚吲哚类生物碱,在抗击癌症方面有显著疗效,其硫酸盐已广泛用于临床30余年,迄今仍是主要的肿瘤用药之一。 制备国内外对提取分离长春碱类的研究由来已久,由于长春花全草中生物碱种类较多,而长春碱、长春新碱在植物内的含量偏低,一般都在万分之几,成为长春类药物市场化的瓶颈问题。通过考

Determinants of ovarian function after response-adapted therapy in patients with advanced Hodgkin’s lymphoma (RATHL): a secondary analysis of a randomised phase 3 trial复制标题

晚期霍奇金淋巴瘤 (RATHL) 患者响应适应治疗后卵巢功能的决定因素: 一项随机3期试验的二次分析

发表时间:2018-09-03

影响因子:35.4

作者: Richard A Anderson

期刊:Lancet Oncol

We recruited female participants from the randomised phase 3 RATHL trial, aged 18-45 years, based on availability of participants at recruiting sites in the UK. The RATHL trial key inclusion criteria were histologically confirmed classic Hodgkin's lymphoma, stage IIB-IV or IIA with adverse features (bulky disease or more than two sites of involvement), no previous treatments, and a performance status of 0-3. As part of RATHL, participants were treated with two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) or AVD followed by an interim PET-CT scan. Participants who had negative interim scans (PET score of 1 to 3 according to the Lugano classification) were randomly assigned (1:1) by use of minimisation, stratified by interim PET score and study centre, to continue ABVD or AVD for four more cycles. Participants with positive scans (PET score of 4 or 5) were escalated to treatment with bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisolone (BEACOPP-14 or escalated BEACOPP) for four cycles. For the protocol-driven prospective cohort substudy, ovarian function was assessed before treatment, during chemotherapy, and then annually for 3 years by use of serum antimüllerian hormone and follicle-stimulating hormone measurements. The RATHL study is registered with ClinicalTrials.gov, number NCT00678327.

译文

我们根据英国招聘网站上参与者的可用性,从18-45岁的随机3期RATHL试验中招募了女性参与者。 RATHL试验的主要纳入标准是经组织学证实的经典霍奇金淋巴瘤,IIB-IV期或IIA期具有不良特征(大块疾病或两个以上受累部位),未曾接受过治疗且工作状态为0-3。作为RATHL的一部分,参与者接受了两个周期的阿霉素,博来霉素,长春碱和达卡巴嗪(ABVD)或AVD治疗,然后进行了临时PET-CT扫描。中期扫描阴性(根据卢加诺分类,PET评分为1到3)的参与者通过最小化被随机分配(1:1),并由中期PET评分和研究中心分层,以继续ABVD或AVD四个周期。扫描结果阳性(PET评分为4或5)的参与者升级为博来霉素,依托泊苷,阿霉素,环磷酰胺,长春新碱,丙卡巴肼和泼尼松龙(BEACOPP-14或升级的BEACOPP)治疗四个周期。对于方案驱动的前瞻性队列研究,在治疗前,化疗期间评估卵巢功能,然后通过使用血清抗苗勒管激素和促卵泡激素的方法每年评估卵巢功能3年。 RATHL研究已在ClinicalTrials.gov上注册,编号为NCT00678327。