Vincristine 英 /vɪn'krɪstiːn/ 美 /vɪn'krɪs,tin/
释 义 n. [药] 长春新碱（一种抗肿瘤药）
例 句 The resistance cell line, ACC/VCR, was induced in the ACC cell line in vitro by progressive concentrations of vincristine (VCR), a drug of choice in the treatment of adenoid cystic carcinoma. 以长春新碱（VCR）为诱导剂，通过浓度递增间断刺激法对人腺样囊性癌细胞系（ACC）进行体外诱导耐药，建立耐VCR的腺样囊性癌细胞系ACC/VCR。
晚期霍奇金淋巴瘤 (RATHL) 患者响应适应治疗后卵巢功能的决定因素: 一项随机3期试验的二次分析
作者： Richard A Anderson
We recruited female participants from the randomised phase 3 RATHL trial, aged 18-45 years, based on availability of participants at recruiting sites in the UK. The RATHL trial key inclusion criteria were histologically confirmed classic Hodgkin's lymphoma, stage IIB-IV or IIA with adverse features (bulky disease or more than two sites of involvement), no previous treatments, and a performance status of 0-3. As part of RATHL, participants were treated with two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) or AVD followed by an interim PET-CT scan. Participants who had negative interim scans (PET score of 1 to 3 according to the Lugano classification) were randomly assigned (1:1) by use of minimisation, stratified by interim PET score and study centre, to continue ABVD or AVD for four more cycles. Participants with positive scans (PET score of 4 or 5) were escalated to treatment with bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisolone (BEACOPP-14 or escalated BEACOPP) for four cycles. For the protocol-driven prospective cohort substudy, ovarian function was assessed before treatment, during chemotherapy, and then annually for 3 years by use of serum antimüllerian hormone and follicle-stimulating hormone measurements. The RATHL study is registered with ClinicalTrials.gov, number NCT00678327.