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Oxaliplatin

肿瘤

关键词肿瘤 药物 结直肠癌

词汇介绍

拓展阅读

解析

Oxaliplatin 

释    义   n. 奥沙利铂(抗肿瘤药)

例    句   To observe the effects of oxaliplatin on proliferation in human colon carcinoma cell lines HT29 in vitro and investigate the mechanism. 观察抗肿瘤药物奥沙利铂对人结肠癌细胞株HT29体外增殖的影响,初步探讨其作用机制。

概述

奥沙利铂又称乐沙定、草酸铂,属于铂类衍生物,临床上用于治疗经氟脲嘧啶治疗失败后的结直肠癌转移的患者,可单独或联合氟尿嘧啶使用,是继顺铂、卡铂之后的第三代新型铂类抗肿瘤化合物,也是迄今为止唯一对结肠直肠癌具有显著活性的络铂类药物。作用原理是通过产生烷化结合物作用于DNA,形成链内和链间交联抑制DNA的合成及复制。同时也对卵巢癌及黑色素瘤细胞系有抑制增生作用。2002年8月,美国食品与药品管理局(FDA)批准了赛诺菲圣特拉堡公司的抗癌药奥沙利铂(oxaliplatin,Eloxatin)用于转移

Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients复制标题

细胞周期蛋白依赖性激酶5 (Cdk5) 的肿瘤表达是预测奥沙利铂治疗转移性结直肠癌患者预后的生物标志物

发表时间:2019-10-11

影响因子:6.2

作者: Vicenç Ruiz de Porras

期刊:Cancers (Basel)

In recent years, an increasing number of studies have shown that elevated expression of cyclin dependent kinase (Cdk5) contributes to the oncogenic initiation and progression of many types of cancers. In this study, we investigated the expression pattern of Cdk5 in colorectal cancer (CRC) cell lines and in a large number of tumor samples in order to evaluate its relevance in this pathogenesis and possible use as a prognostic marker. We found that Cdk5 is highly expressed and activated in CRC cell lines and that silencing of the kinase decreases their migration ability. In tumor tissues, Cdk5 is overexpressed compared to normal tissues due to a copy number gain. In patients with localized disease, we found that high Cdk5 levels correlate with poor prognosis, while in the metastatic setting, this was only the case for patients receiving an oxaliplatin-based treatment. When exploring the Cdk5 levels in the consensus molecular subtypes (CMS), we found the lowest levels in subtype 1, where high Cdk5 again was associated with a poorer prognosis. In conclusion, we confirm that Cdk5 is involved in CRC and disease progression and that it could serve as a prognostic and predictive biomarker in this disease.

译文

近年来,越来越多的研究表明,细胞周期蛋白依赖性激酶(Cdk5)的高表达有助于多种类型癌症的致癌性启动和发展。在这项研究中,我们研究了Cdk5在结直肠癌(CRC)细胞系和大量肿瘤样品中的表达模式,以评估其在该发病机制中的相关性,并可能将其用作预后指标。我们发现Cdk5在CRC细胞系中高度表达和激活,而激酶的沉默降低了它们的迁移能力。在肿瘤组织中,由于拷贝数增加,Cdk5与正常组织相比过表达。在患有局部疾病的患者中,我们发现高Cdk5水平与不良预后相关,而在转移性患者中,仅接受基于奥沙利铂治疗的患者才有这种情况。探索共有分子亚型(CMS)中的Cdk5水平时,我们发现亚型1中的最低水平,其中高Cdk5再次与较差的预后相关。总之,我们确认Cdk5参与CRC和疾病进展,并且可以作为该疾病的预后和预测生物标志物。