肿瘤
词汇介绍
拓展阅读
解析
Modified 英 /ˈmɒdɪfaɪd/ 美 /mɑdəˌfaɪd/
释 义 adj. 改进的，修改的；改良的；v. 修改；缓和（modify的过去分词）
同根词 modifiable adj. 可修饰的；可更改的
modification n. 修改，修正；改变
modify vi. 修改
modify vt. 修改，修饰；更改
例 句 At the other end of the spectrum of possibilities, the team modified all of the end dates after each iteration started. 在这个可能值范围的另一个端点，这个团队在每次迭代开始后，修改了所有迭代的终止日期。
FOLFOX6
释 义 n. 胃肠道肿瘤常用的化疗方案
例 句 To study the effect of aflibercept plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) induction neoadjuvant chemotherapy prior to standard chemoradiotherapy and total mesorectal excision (TME) surgery in patients with high-risk rectal adenocarcinoma. 研究阿柏西普联合改良氟尿嘧啶、亚叶酸钙和奥沙利铂（mFOLFOX6）在标准放化疗和全肠系膜切除（TME）手术前对高危直肠腺癌患者进行新辅助化疗的效果。
概述
复制标题Aflibercept联合改良FOLFOX6诱导化疗在标准放化疗和手术治疗高危直肠腺癌患者中的作用: GEMCAD 1402随机临床试验
发表时间：2019-08-29
影响因子：22.4
作者： Carlos Fernández-Martos
期刊：JAMA Oncol
IMPORTANCE: Preclinical studies suggest that a vascular endothelial growth factor (VEGF) blockade may play a role in the preoperative treatment of rectal adenocarcinoma; however, how to combine anti-VEGF drugs with neoadjuvant chemotherapy (CT) and/or chemoradiotherapy (CRT) remains controversial. OBJECTIVE: To study the effect of aflibercept plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) induction CT prior to standard CRT and total mesorectal excision (TME) surgery in patients with high-risk rectal adenocarcinoma. DESIGN, SETTING, AND PARTICIPANTS: In the Grupo Español Multidisciplinar En Cancer Digestivo (GEMCAD) 1402 phase 2 randomized clinical trial, 180 patients aged 18 to 75 years, identified by centrally reviewed magnetic resonance imaging to have mrT3c-d/T4/N2 rectal adenocarcinoma, were enrolled from 20 treatment centers in Spain between January 2015 and March 2017. Patients were randomized in a 2:1 treatment to control arm ratio. The primary end point was evaluated at 2 interim and 1 final analyses. The study was designed to perform hypothesis testing at α = 2 and β = 2. A 2-sided P value of <1984 in the final analysis of the intention-to-treat population was the threshold for considering the experimental treatment to be more effective than the control.
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