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首页 > 医学词汇大全 > intraepithelial neoplasia
intraepithelial neoplasia

肿瘤

关键词肿瘤 疾病 癌前病变

词汇介绍

拓展阅读

解析

Intraepithelial   /'intrə,epi'θi:liəl/

释    义   adj. 上皮内的

例    句   To study the expression of proliferating cell nuclear antigen(PCNA) and explore whether cell proliferation play an important role in the tissue of prostate intraepithelial neoplasia(PIN). 研究细胞增殖核抗原(PCNA)在前列腺上皮内瘤(PIN)组织中的表达,探讨细胞增殖在前列腺肿瘤形成过程中的作用。

 

Neoplasia   英 /,niːə(ʊ)'pleɪzɪə/   美 /,nio'pleʒɪr/

释    义   n. 瘤形成

例    句   To study the relationship among different types of human papilloma virus, cervical intraepithelial neoplasia and cervical carcinoma. 探讨不同类型人乳头瘤病毒与宫颈上皮内瘤变和宫颈癌的关系。

概述

上皮内瘤变(IN)和异型增生是同义词;是指基底膜以上上皮的一种非浸润性肿瘤性改变,属于癌前病变,通常表现为组织结构和细胞学存在改变,这些改变被发现可以反映出那些能够引发浸润性癌的潜在分子学异常。病变具有基因的克隆性转变,容易发展为浸润和转移。上皮内瘤变的类型以及形态学特征与这些浸润性肿瘤的前驱病变相关,每个器官各不相同。上皮内瘤变定义的关键在于,所有病变均具有可辨识的形态,具有恶变倾向且无浸润。1960年Richard首次将上皮内瘤变这一名词用于子宫颈黏膜鳞状上皮的癌前变化,它的正确涵义是强

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells复制标题

胰腺导管腺癌进展过程中ECM的蛋白质组学分析揭示了肿瘤和间质细胞的不同贡献

发表时间:2019-09-24

影响因子:9.6

作者: Richard O. Hynes

期刊:PNAS

Pancreatic ductal adenocarcinoma (PDAC) has prominent extracellular matrix (ECM) that compromises treatments yet cannot be nonselectively disrupted without adverse consequences. ECM of PDAC, despite the recognition of its importance, has not been comprehensively studied in patients. In this study, we used quantitative mass spectrometry (MS)-based proteomics to characterize ECM proteins in normal pancreas and pancreatic intraepithelial neoplasia (PanIN)- and PDAC-bearing pancreas from both human patients and mouse genetic models, as well as chronic pancreatitis patient samples. We describe detailed changes in both abundance and complexity of matrisome proteins in the course of PDAC progression. We reveal an early up-regulated group of matrisome proteins in PanIN, which are further up-regulated in PDAC, and we uncover notable similarities in matrix changes between pancreatitis and PDAC. We further assigned cellular origins to matrisome proteins by performing MS on multiple lines of human-to-mouse xenograft tumors. We found that, although stromal cells produce over 90% of the ECM mass, elevated levels of ECM proteins derived from the tumor cells, but not those produced exclusively by stromal cells, tend to correlate with poor patient survival. Furthermore, distinct pathways were implicated in regulating expression of matrisome proteins in cancer cells and stromal cells.

译文

胰腺导管腺癌(PDAC)具有突出的细胞外基质(ECM),会损害治疗效果,但不能非选择性地破坏其而不产生不良后果。尽管PDAC的ECM非常重要,但尚未在患者中进行全面研究。在这项研究中,我们使用基于定量质谱(MS)的蛋白质组学来表征正常胰腺以及来自人类患者和小鼠遗传模型以及慢性胰腺炎患者的胰腺和胰腺上皮内瘤变(PanIN)和带有PDAC的胰腺中的ECM蛋白。样品。我们描述了在PDAC进展过程中基质蛋白的丰度和复杂性的详细变化。我们揭示了PanIN中一组早期上调的基质蛋白,这些蛋白在PDAC中进一步上调,并且我们发现胰腺炎与PDAC之间的基质变化具有显着相似性。我们进一步通过在人与小鼠异种移植肿瘤的多系上进行MS,将细胞起源分配给了基质蛋白。我们发现,尽管基质细胞产生的ECM质量超过90%,但源自肿瘤细胞而不是仅由基质细胞产生的ECM蛋白水平升高往往与患者存活率低有关。此外,在调节癌细胞和基质细胞中基质蛋白的表达中涉及不同的途径。