释 义 adj. 上皮内的
例 句 To study the expression of proliferating cell nuclear antigen(PCNA) and explore whether cell proliferation play an important role in the tissue of prostate intraepithelial neoplasia(PIN). 研究细胞增殖核抗原（PCNA）在前列腺上皮内瘤（PIN）组织中的表达，探讨细胞增殖在前列腺肿瘤形成过程中的作用。
Neoplasia 英 /,niːə(ʊ)'pleɪzɪə/ 美 /,nio'pleʒɪr/
释 义 n. 瘤形成
例 句 To study the relationship among different types of human papilloma virus, cervical intraepithelial neoplasia and cervical carcinoma. 探讨不同类型人乳头瘤病毒与宫颈上皮内瘤变和宫颈癌的关系。
作者： Richard O. Hynes
Pancreatic ductal adenocarcinoma (PDAC) has prominent extracellular matrix (ECM) that compromises treatments yet cannot be nonselectively disrupted without adverse consequences. ECM of PDAC, despite the recognition of its importance, has not been comprehensively studied in patients. In this study, we used quantitative mass spectrometry (MS)-based proteomics to characterize ECM proteins in normal pancreas and pancreatic intraepithelial neoplasia (PanIN)- and PDAC-bearing pancreas from both human patients and mouse genetic models, as well as chronic pancreatitis patient samples. We describe detailed changes in both abundance and complexity of matrisome proteins in the course of PDAC progression. We reveal an early up-regulated group of matrisome proteins in PanIN, which are further up-regulated in PDAC, and we uncover notable similarities in matrix changes between pancreatitis and PDAC. We further assigned cellular origins to matrisome proteins by performing MS on multiple lines of human-to-mouse xenograft tumors. We found that, although stromal cells produce over 90% of the ECM mass, elevated levels of ECM proteins derived from the tumor cells, but not those produced exclusively by stromal cells, tend to correlate with poor patient survival. Furthermore, distinct pathways were implicated in regulating expression of matrisome proteins in cancer cells and stromal cells.