释 义 n. 吉西他滨或胞苷或健泽（药物名）
例 句 Many pancreatic tumor cells are resistant to gemcitabine, which makes the disease very difficult to treat. 很多胰腺肿瘤细胞对吉西他滨耐药，导致这种疾病现在很难得到有效治疗。
作者： Girgis Obaid
Here, we report 1) a systematic multivariant tuning approach to engineer (Cet, anti-EGFR mAb) photoimmunonanoconjugates (PINs), and 2) stroma-rich heterotypic PDAC in vitro and in vivro models incorporating patient-derived pancreatic cancer-associated fibroblasts (PCAFs) that recapitulate the desmoplasia observed in the clinic. These offer a comprehensive, disease-specific framework for the development of Cet-PINs. Specificity-tuning of the PINs, in terms of PS lipid anchoring, electrostatic modulation, Cet orientation and surface densities, achieved ca. 16-fold binding specificities and rapid penetration of the heterotypic organoids within 1 h, and provided a ca. 16-fold enhancement in molecular targeted NIR photodestruction. As a demonstration of their inherent amenability for multifunctionality, encapsulation of high gemcitabine hydrochloride, 5-fluorouracil and oxaliplatin payloads within the Cet-PINs further improved their anti-tumor efficacy in the heterotypic organoids. In heterotypic desmoplastic tumors, the Cet-PINs efficiently penetrated up to 470 μm away from blood vessels and photodynamic activation resulted in substantial tumor necrosis, which was not achieved in T47D tumors (low EGFR), or using untargeted constructs in both tumor types. Photodynamic activation of the Cet-PINs in the heterotypic desmoplastic tumors resulted in collagen photomodulation, with a 1.5-fold reduction in collagen density, suggesting that PDP may also hold potential for conquering desmoplasia.