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首页 > 医学词汇大全 > Gemcitabine
Gemcitabine

肿瘤

关键词肿瘤 药物 胰腺癌

词汇介绍

拓展阅读

解析

Gemcitabine 

释    义   n. 吉西他滨或胞苷或健泽(药物名)

例    句   Many pancreatic tumor cells are resistant to gemcitabine, which makes the disease very difficult to treat. 很多胰腺肿瘤细胞对吉西他滨耐药,导致这种疾病现在很难得到有效治疗。

概述

吉西他滨是一种破坏细胞复制的二氟核苷类抗代谢药物,为脱氧胞苷的水溶性类似物,是核糖核苷酸还原酶抑制剂。临床主要用于治疗局部进展性或转移性非小细胞肺癌和不能手术的晚期或转移性胰腺癌。其成份是盐酸吉西他滨。 适应症可用于局限晚期或已转移的非小细胞肺癌;局限晚期或已转移的胰腺癌。吉西他滨与紫杉醇联合可用于治疗经辅助/新辅助化疗后复发、不能切除的、局部复发或转移性乳腺癌。在有些国家也被批准用于膀胱癌、宫颈癌、卵巢癌、前列腺癌等实体肿瘤。 配制方法每瓶(含吉西他滨200 

Impacting pancreatic cancer therapy in heterotypic in vitro organoids and in vivo tumors with specificity-tuned, NIR-activable photoimmunonanoconjugates: towards conquering desmoplasia?复制标题

影响体外异型类器官和体内肿瘤的胰腺癌治疗,具有特异性调谐、NIR激活的光免疫结合物: 走向征服桥皮瘤发育?

发表时间:2019-10-04

影响因子:12.3

作者: Girgis Obaid

期刊:Nano Lett.

Here, we report 1) a systematic multivariant tuning approach to engineer (Cet, anti-EGFR mAb) photoimmunonanoconjugates (PINs), and 2) stroma-rich heterotypic PDAC in vitro and in vivro models incorporating patient-derived pancreatic cancer-associated fibroblasts (PCAFs) that recapitulate the desmoplasia observed in the clinic. These offer a comprehensive, disease-specific framework for the development of Cet-PINs. Specificity-tuning of the PINs, in terms of PS lipid anchoring, electrostatic modulation, Cet orientation and surface densities, achieved ca. 16-fold binding specificities and rapid penetration of the heterotypic organoids within 1 h, and provided a ca. 16-fold enhancement in molecular targeted NIR photodestruction. As a demonstration of their inherent amenability for multifunctionality, encapsulation of high gemcitabine hydrochloride, 5-fluorouracil and oxaliplatin payloads within the Cet-PINs further improved their anti-tumor efficacy in the heterotypic organoids. In heterotypic desmoplastic tumors, the Cet-PINs efficiently penetrated up to 470 μm away from blood vessels and photodynamic activation resulted in substantial tumor necrosis, which was not achieved in T47D tumors (low EGFR), or using untargeted constructs in both tumor types. Photodynamic activation of the Cet-PINs in the heterotypic desmoplastic tumors resulted in collagen photomodulation, with a 1.5-fold reduction in collagen density, suggesting that PDP may also hold potential for conquering desmoplasia.

译文

在这里,我们报告1)一种针对工程师(Cet,抗EGFR mAb)光免疫偶联物(PIN)的系统化多变量调整方法,以及2)在体外和体内结合了患者来源的胰腺癌相关成纤维细胞的体内模型中,富含基质的异型PDAC( PCAFs)概括了临床观察到的增生。这些为Cet-PIN的开发提供了针对疾病的全面框架。在PS脂质锚固,静电调制,Cet方向和表面密度方面,可以实现PIN的特异性调节。 16倍的结合特异性和异型类器官的快速渗透在1小时内,并提供了约。分子靶向的近红外光降解能力提高了16倍。为了证明其固有的多功能性,将高吉西他滨盐酸盐,5-氟尿嘧啶和奥沙利铂有效载荷包裹在Cet-PIN中可以进一步提高其在异型类器官中的抗肿瘤功效。在异型增生性肿瘤中,Cet-PINs可以有效地从血管渗透至470μm,并且光动力激活会导致实质性肿瘤坏死,而这在T47D肿瘤(低EGFR)中或在两种肿瘤类型中均使用非靶向构建体均无法实现。异型增生性肿瘤中Cet-PINs的光动力激活导致胶原蛋白的光调节,胶原蛋白密度降低1.5倍,这表明PDP也可能具有征服增生的潜力。