Mismatch 英 /ˌmɪsˈmætʃ/ 美 /ˌmɪsˈmætʃ/
释 义 v. 使配错；使不适当地在一起；
例 句 Our minds are not modern, and many of our woes have to do with this mismatch between our Stone-age psychologies and the world in which we now live.我们的思想并不现代，事实上，生活中的许多不幸都与我们旧石器时代的心理特征以及当下生活世界之间的不相匹配有关。
Repair 英 /rɪˈpeə(r)/ 美 /rɪˈper/
释 义 v. 修理；修复，补救；（使）重归于好；（结伴）去；
例 句 We clean and repair the machines as a matter of routine.我们定期清洗和修理机器。
作者： Germano G
Molecular alterations in genes involved in DNA mismatch repair (MMR) promote cancer initiation and foster tumour progression. Cancers deficient in MMR frequently show favourable prognosis and indolent progression. The functional basis of the clinical outcome of patients with tumours that are deficient in MMR is not clear. Here we genetically inactivate MutL homologue 1 (MLH1) in colorectal, breast and pancreatic mouse cancer cells. The growth of MMR-deficient cells was comparable to their proficient counterparts in vitro and on transplantation in immunocompromised mice. By contrast, MMR-deficient cancer cells grew poorly when transplanted in syngeneic mice. The inactivation of MMR increased the mutational burden and led to dynamic mutational profiles, which resulted in the persistent renewal of neoantigens in vitro and in vivo, whereas MMR-proficient cells exhibited stable mutational load and neoantigen profiles over time. Immune surveillance improved when cancer cells, in which MLH1 had been inactivated, accumulated neoantigens for several generations. When restricted to a clonal population, the dynamic generation of neoantigens driven by MMR further increased immune surveillance. Inactivation of MMR, driven by acquired resistance to the clinical agent temozolomide, increased mutational load, promoted continuous renewal of neoantigens in human colorectal cancers and triggered immune surveillance in mouse models.