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首页 > 医学词汇大全 > Adrenocortical Carcinoma
Adrenocortical Carcinoma

肾内泌尿

关键词肾内泌尿 疾病 肾上腺皮质癌

词汇介绍

拓展阅读

解析

Adrenocortical  英  /ə,driːnəʊ'kɔːtɪkəl/  美  /ə,drino'kɔrtəkəl/

释    义   adj. 肾上腺皮质的

例    句   Methods: The clinical data of 15 patients were summarized including 13 cases of congenital adrenal hyperplasia, and 2 cases of adrenocortical carcinoma.方法:总结15例肾上腺性征综合征患者的临床资料,其中先天性肾上腺皮质增生13例,肾上腺皮质癌2例。

 

Carcinoma  英  /ˌkɑːsɪˈnəʊmə/  美  /ˌkɑːrsɪˈnoʊmə/

释    义   n. [肿瘤] 癌

例    句   Another study discovered that people who ate the highest amounts of fruits and veggies were 54 percent less likely to develop squamous cell carcinoma.另一项研究表明,那些食用大量水果和蔬菜的人患上鳞状细胞癌的几率比其他人小54%。

概述

  肾上腺皮质癌又称ACC,是临床上比较少见的一种原发于肾上腺皮质的恶性肿瘤。这种癌症的发病率比较低,而恶性程度高,预后状况不好,在早期也不容易确诊。该病病情重、进展快,肿瘤侵润可以穿过包膜,晚期可以转移到淋巴结肝肺等处,出现重度的cushing综合征的表现,担忧显著的高血压、低血钾,可以同时产生雄激素,女性呈多毛、痤疮,有腹痛、背痛、侧腹痛等症状。肾上腺皮质癌多见于12岁以下儿童。   病因   肾上腺皮质癌的病因主要

Adrenocortical Carcinoma - Towards Genomics Guided Clinical Care复制标题

肾上腺皮质癌-走向基因组学指导的临床护理

发表时间:2019-09-15

影响因子:28.8

作者: Crona J

期刊:Nat Rev Endocrinol

Adrenocortical carcinoma (ACC) is an aggressive and rare neoplasm that originates in the cortex of the adrenal gland. The disease is associated with heterogeneous but mostly poor outcomes and lacks effective pharmaceutical treatment options. Multi-omics studies have defined the landscape of molecular alterations in ACC. Specific molecular signatures can be detected in body fluids, potentially enabling improved diagnostic applications for patients with adrenal tumours. Importantly, pan-molecular data sets further reveal a spectrum within ACC, with three major subgroups that have different disease outcomes. These new subgroups have value as prognostic biomarkers. Research has revealed that the p53-RB and the WNT-β-catenin pathways are common disease drivers in ACC. However, these pathways remain difficult to target by therapeutic interventions. Instead, a unique characteristic of ACC is steroidogenic differentiation, which has emerged as a potential treatment target, with several agents undergoing preclinical or clinical investigations. Finally, a large proportion of ACC tumours have genetic profiles that are associated with promising therapeutic responsiveness in other cancers. All these opportunities now await translation from the laboratory into the clinical setting, thereby offering a real potential of improved survival outcomes and increased quality of life for patients with this serious condition.

译文

肾上腺皮质癌(ACC)是一种侵袭性且罕见的肿瘤,起源于肾上腺皮质。该病与异质性相关,但大多为不良预后且缺乏有效的药物治疗选择。多组学研究已经定义了ACC中分子改变的态势。可以在体液中检测到特定的分子标记,从而有可能改善对肾上腺肿瘤患者的诊断应用。重要的是,全分子数据集进一步揭示了ACC内的频谱,其中三个主要亚组的疾病预后不同。这些新的亚组具有作为预后生物标志物的价值。研究表明,p53-RB和WNT-β-catenin途径是ACC的常见疾病驱动因素。然而,这些途径仍然难以通过治疗干预来靶向。取而代之的是,ACC的独特特征是类固醇生成分化,它已成为一种潜在的治疗靶标,一些药物正在接受临床前或临床研究。最后,很大一部分ACC肿瘤具有与其他癌症中有希望的治疗反应性相关的遗传特征。现在,所有这些机会都等待着从实验室转换到临床环境,从而为这种严重疾病的患者提供了提高生存率和提高生活质量的真正潜力。