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renin

肾内泌尿

关键词肾内泌尿 基础研究专业名词

词汇介绍

拓展阅读

解析

renin   英 /'riːnɪn/   美 /'rɛnɪn/

释    义   n. [生化] 肾素;高血压蛋白原酶

例    句   And small increases in renin and aldosterone at four weeks are similar to that which occurs when diuretics are given to reduce blood pressure.并且,四个月内肾激素和醛固酮指标的小幅度增长,也与服用利尿剂降血压所产生的效果差不多。

概述

肾素,也被称为血管紧张素原酶,是肾小球旁器(也称球旁复合体)的球旁颗粒细胞释放的一种蛋白水解酶,是肾素-血管紧张素系统的组成部分。 体内生理调控 肾素分泌调节机制极其复杂性,其合成和分泌受多种因素的调节,其中涉及到许多细胞内信息分子,并参与高血压形成和发展。 ①致密斑对肾素分泌的生理性调节 致密斑处管内液流速减慢或该区Na+浓度降低时,可激活其上皮侧细胞膜Na-2Cl-K协同转运机制,提高细胞内Na+浓度,

The (pro)renin receptor in health and disease复制标题

健康与疾病中的 (原) 肾素受体

发表时间:2019-11-06

影响因子:19.7

作者: Ichihara A

期刊:Nat Rev Nephrol

The (pro)renin receptor ((P)RR; also known as ATP6AP2) was cloned in 2002 as a single-transmembrane receptor composed of 350 amino acids. The (P)RR binds renin and prorenin and is widely distributed in the body. At least three intracellular forms of (P)RR exist: the full-length protein, an amino-terminal fragment and a carboxy-terminal fragment. The fragments are products of full-length (P)RR cleaved by processing enzymes such as furin, ADAM19 (ref.4) and site 1 protease (S1P). The amino-terminal fragment is secreted extracellularly as the soluble (P)RR (s(P)RR), whereas the carboxy-terminal fragment (also known as M8-9) remains inside the cell and interacts with vacuolar H+-ATPase (V-ATPase).

译文

肾素受体(pro)在2002年被克隆为一个由350个氨基酸组成的跨膜受体。(P)RR结合肾素和前肾素,广泛分布于体内。至少有三种胞内形式的(P)RR存在:全长蛋白、氨基末端片段和羧基末端片段。这些片段是由furin、ADAM19(参考文献4)和site 1蛋白酶(S1P)等加工酶裂解的全长(P)RR的产物。氨基末端片段作为可溶性(P)RR(s(P)RR)在细胞外分泌,而羧基末端片段(又称M8-9)留在细胞内并与空泡H+-ATPase(V-ATPase)相互作用。