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Optical microscopic findings of the behavior of perflubutane microbubbles outside and inside Kupffer cells during diagnostic ultrasound examination.
诊断性超声检查期间枯否细胞内外过氟丁烷微泡行为的光学显微镜观察。

摘要

PURPOSE:To investigate the behavior of perflubutane microbubbles outside and inside Kupffer cells during diagnostic ultrasound (US) examination, and to determine the thresholds of the acoustic pressure of different kinds of behavior.
METHODS:Acoustic behavior of perflubutane microbubbles inside and outside Kupffer cells in an acoustic field induced by a clinical US transducer and equipment was optically observed in vitro. The acoustic pressure was measured simultaneously by a calibrated hydrophone and an oscilloscope.
RESULTS:The acoustic behavior of microbubbles was optically categorized as stabilization, oscillation, transposition, shrinkage, and destruction. The mechanical index (MI) displayed on the US equipment correlated well with the acoustic pressure at the level of microbubbles measured hydrophonically. At a frame rate of 15 Hz with a frequency of 3.5 MHz and pulse repetition frequency of 3 KHz, the thresholds in term of MI for free microbubbles to begin oscillation, reach best oscillation, transposition, shrinkage, and destruction were 0.21, 0.44, 0.53, 0.75, and 1.03, respectively. Although adherent and phagocytosed microbubbles showed more stability enduring insonation compared with free microbubbles, the thresholds of shrinkage and destruction were MI 1.03 and 1.18 for adherent microbubbles, and 1.18 and 1.37 for phagocytosed microbubbles, respectively. Neither oscillation nor transposition of microbubbles inside Kupffer cells was observed microscopically. No cell damage because of microbubbles destruction was found in the present study.
CONCLUSION:Perflubutane microbubbles outside and inside Kupffer cells respond to external US insonation with same parameters of a clinical contrast-enhanced US study according to the acoustic pressure. Free microbubbles behave as stabilization, oscillation, transposition, shrinkage, and destruction under insonation. The adherent and phagocytosed microbubbles are more stable under insonation than free microbubbles, but still respond showing shrinkage and destruction when MI is over 1.03.

译文

目的: 研究诊断超声 (US) 检查过程中枯否细胞内外过氟丁烷微泡的行为,并确定不同行为的声压阈值。
方法: 体外光学观察临床美国换能器和设备诱导的声场中枯否细胞内外过氟丁烷微泡的声学行为。声压由校准的水听器和示波器同时测量。
结果: 微泡的声学行为在光学上分为稳定、振荡、换位、收缩和破坏。美国设备上显示的机械指数 (MI) 与水声测量的微气泡水平的声压有很好的相关性。在频率为 3.5 MHz 、脉冲重复频率为 3 KHz 、频率为 15 Hz 的帧速率下,自由微泡开始振荡、达到最佳振荡、换位、收缩和破坏分别为 0.21 、 0.44 、 0.53 、 0.75 和 1.03。尽管与游离微泡相比,粘附微泡和吞噬微泡显示出更稳定的持久性,但粘附微泡的收缩和破坏阈值分别为 MI 1.03 和 MI 1.18,吞噬微泡的收缩和破坏阈值分别为 MI 1.18 和 MI 1.37。显微镜下未观察到 Kupffer 细胞内微泡的振荡或转位。本研究未发现由于微泡破坏造成的细胞损伤。
结论: Kupffer 细胞内外的过氟丁烷微泡对外部 US 干扰的反应与根据声压进行的临床对比增强 US 研究的参数相同。自由微泡表现为稳定、振荡、换位、收缩和破坏。粘附和吞噬的微泡在不稳定的情况下比游离微泡更稳定,但是当 MI 超过 1.03 时,仍然表现出收缩和破坏。

Ultrasound Examination

肾内泌尿 检查方式 诊断方式
概述  :  

超声检査(ultrasound examination)是根据声像图特征对疾病作出诊断。超声波为一种机械波,具有反射、散射、衰减及多普勒效应等物理特性,通过各种类型的超声诊断仪,将超声发射到人体内,在传播过程中遇到不同组织或器官的分界面时,将发生反射或散射形成回声,这些携带信息的回声信号经过接收、放大和处理后,以不同形式将图像显示于荧光屏上,即为声像图(ultrasonogram或echogram),观察分析声像图并结合临床表现可对疾病作出诊断。

ultrasound   英 [ˈʌltrəsaʊnd] 美 [ˈʌltrəsaʊnd]

释    义   n. 超声;超音波

例    句   A week or so before your surgery, your doctor performs a painless ultrasound test to measure the size and shape of your eye.手术之前的一周左右,医生会做一些无痛的超声检查,以便测量眼球的大小和形状。

 

examination   英 [ɪɡˌzæmɪˈneɪʃn]   美 [ɪɡˌzæmɪˈneɪʃn]

释    义   n. 考试;检查;查问

例    句   Histopathologic examination reveals intense hyperplasia.组织病理学检查显示严重增生。

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