osteosarcoma 英 /,ɒstɪəʊsɑː'kəʊmə/ 美 /,ɑstiosɑr'komə/
释 义 n. [肿瘤] 骨肉瘤
例 句 Osteosarcoma is one of the commonest primary malignant tumors of bone. It metastasizes fast, and has a high death rate. 骨肉瘤是原发于骨的肿瘤中最常见的一类恶性肿瘤，转移快，死亡率高。
作者： Bayles Ian
期刊：J Clin Invest
Despite progress in intensification of therapy, outcomes for patients with metastatic osteosarcoma (OS) have not improved in thirty years. We developed a system that enabled preclinical screening of compounds against metastatic OS cells in the context of the native lung microenvironment. Using this strategy to screen a library of epigenetically targeted compounds, we identified inhibitors of CDK12 to be most effective, reducing OS cell outgrowth in the lung by more than 90% at submicromolar doses. We found that knockout of CDK12 in an in vivo model of lung metastasis significantly decreased the ability of OS to colonize the lung. CDK12 inhibition led to defects in transcription elongation in a gene length- and expression-dependent manner.