Meta-analysis Myasthenia gravis Thyroid autoimmunity Thyroid disorders Thyroid dysfunction
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摘要

BACKGROUND:Our purpose was to determine the prevalence of thyroid disorders in myasthenia gravis (MG) or whether MG was associated with an increased risk of thyroid disorders.
METHODS:Pubmed, Embase, Web of Science, Cochrane database, Google Scholar and the Chinese Biomedical Databases were searched about the relationship between thyroid disorders and myasthenia gravis up to November 30, 2018, without language restrictions. The prevalence and relative risk (RR) for thyroid disorders were pooled by the R and STATA software.
RESULTS:39 papers with 24,927 MG patients were ultimately included for analysis in this meta-analysis. The pooled estimate of thyroid autoimmunity prevalence in MG patients was 10.1% (95%CI 6.7%-15.1%). Subgroups in patients with thyroid autoimmunity showed the prevalence of positive TGAb was the highest in MG patients (12.6%, 95%CI 8.1%-19.1%), followed by GD (6.0%, 95%CI 4.2%-8.5%), HT (4.6%, 95%CI 1.9%-10.5%). Moreover, the pooled estimated prevalence of thyroid dysfunction in MG patients was 6.8% (95%CI 4.6%-9.8%). After stratification, the results showed the prevalence of hyperthyroidism and hypothyroidism in MG cases were 5.6% (95%CI 3.9%-8.0%) and 2.6% (95%CI 1.7%-4.1%), respectively. In addition, meta-analysis of 2 studies showed that MG was significantly associated with the increased risk of thyroid autoimmunity (OR = 2.86; 95%CI 1.54-5.28, P = .001).
CONCLUSIONS:This systemic review and meta-analysis provides reliable evidence that thyroid disorders are prevalent in MG, especially TGAb positivity, GD, hyperthyroidism, and HT, and MG is associated with increased risk for thyroid autoimmunity.

译文

背景: 我们的目的是确定重症肌无力 (MG) 甲状腺疾病的患病率,或者 MG 是否与甲状腺疾病风险增加相关。
方法: 检索 Pubmed 、 Embase 、 Web of Science 、 Cochrane 数据库、 Google Scholar 和中国生物医学数据库,搜索甲状腺疾病与重症肌无力之间的关系,直到 2018年11月30日,没有语言限制。用 R 和 STATA 软件合并甲状腺疾病的患病率和相对风险 (RR)。
结果: 在本次荟萃分析中,最终纳入了 39 篇 24,927 MG 患者的论文进行分析。MG 患者甲状腺自身免疫患病率的合并估计为 10.1% (6.7% 置信区间 15.1%-)。甲状腺自身免疫患者的亚组显示,MG 患者的 TGAb 阳性患病率最高 (12.6%,8.1% CI 19.1%-6.0%),其次是 GD (, 95% CI 4.2%-8.5%),HT (4.6%,95% CI 1.9%-10.5%)。此外,MG 患者甲状腺功能障碍的合并估计患病率为 6.8% (95% CI 4.6%-9.8%)。分层后,结果显示 MG 病例的甲状腺功能亢进和甲减患病率分别为 5.6% (3.9% 置信区间 8.0%-2.6%) 和 1.7% (4.1% 置信区间-)。此外,两项研究的荟萃分析显示,MG 与甲状腺自身免疫风险的增加显著相关 (or =-2.86; 95% CI 1.54-5.28,p =-。 001)。
结论: 该系统综述和荟萃分析提供了可靠的证据,证明甲状腺疾病在 MG 中普遍存在,尤其是 TGAb 阳性、 GD 、甲状腺功能亢进和 HT, MG 与甲状腺自身免疫风险增加有关。

Myasthenia

儿科 自身免疫性疾病 疾病
概述  :  

肌无力是一种由乙酰胆碱受体(AChR)抗体介导、细胞免疫依赖、补体参与,累及神经肌肉接头突触后膜,引起神经肌肉接头传递障碍,出现骨骼肌收缩无力的获得性自身免疫性疾病。极少部分肌无力患者由抗-MuSK抗体、抗LRP4抗体介导。年平均发病率约为8.0-20.0/10万人。肌无力在各个年龄阶段均可发病。在40岁之前,女性发病率高于男性;在40-50岁之间男女发病率相当;在50岁之后,男性发病率略高于女性。临床表现全身骨骼肌均可受累。但在发病早期可单独出现眼外肌、咽喉肌或肢体肌肉无力;颅神经支配的

myasthenia 英 /,maɪəs'θiːnɪə/ 美 /,maɪəs'θinɪə/

释    义   n. [内科] 肌无力;肌肉衰弱

例    句   Emergency thymectomy is the treatment of choice for crisis of myasthenia gravis. 外科手术是治疗重症肌无力危象的方法之一。

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