儿科
词汇介绍
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解析
growth 英 /ɡrəʊθ/ 美 /ɡroʊθ/
释 义 n. 增长；发展；生长；种植
例 句 The research areas cover diabetes, obesity, growth hormone deficiency and haemophilia. 研发领域覆盖糖尿病，肥胖症，生长激素缺乏症及血友病等疾病。
hormone 英 /ˈhɔːməʊn/ 美 /ˈhɔːrmoʊn/
释 义 n. [生理] 激素，荷尔蒙
例 句 Androgen deficiency causes long Bones to continue growing after they would normally stop. Overproduction of growth hormone-usually due to a tumour-causes pituitary gigantism (see pituitary gland). 雄激素缺乏会造成原本应停止成长的长骨骨继续成长。生长激素分泌过多--通常是肿瘤所致--会导致脑下垂体性巨人症。
deficiency 英 /dɪˈfɪʃnsi/ 美 /dɪˈfɪʃnsi/
释 义 n. 缺陷，缺点；缺乏；不足的数额
例 句 The study looked at patients treated during childhood for growth hormone deficiency or shortstature of unknown cause. 这个研究着眼于那些在儿童期因生长激素缺乏或者不明原因的身材短小而接受治疗的患者。
概述
Autoimmune pituitary disease: New concepts with clinical implications
复制标题
自身免疫性垂体疾病: 具有临床意义的新概念
发表时间：2019-09-12
影响因子：15.2
作者： Yamamoto Masaaki
期刊：Endocr Rev
Circulating anti-PIT-1 antibody is a disease marker, and PIT-1-reactive cytotoxic T cells (CTLs) play a pivotal role in disease development. In addition, isolated adrenocorticotropic hormone (ACTH) deficiency appears to be caused by autoimmunity to corticotrophs; however, the pathogenesis remains unclear. A recently described case of isolated ACTH deficiency with large cell neuroendocrine carcinoma (LCNEC) showed ectopically expressed proopiomelanocortin (POMC), and circulating anti-POMC antibody and POMC-reactive CTLs were also detected. As CTL infiltrations around corticotrophs were also observed, isolated ACTH deficiency may be associated at least in part with a paraneoplastic syndrome. Although several underlying mechanisms for pituitary autoimmunity have been proposed, these observations highlight the importance of paraneoplastic syndrome as a cause of pituitary autoimmune disease. In this review, we focus on the pathophysiology and connection of anti-PIT-1 hypophysitis and isolated ACTH deficiency and discuss the state-of-art knowledge for understanding pituitary autoimmunity.
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