摘要

The availability of synthetic recombinant human growth hormone (GH) in potentially unlimited quantities since the 1980s has improved understanding of the many nonstatural effects of GH on metabolism, body composition, physical and psychological function, as well as the consequences of GH deficiency in adult life. Adult GH deficiency is now recognized as a distinct if nonspecific syndrome with considerable adverse health consequences. GH replacement therapy in lower doses than those used in children can reverse many of these abnormalities and restore functional capacities toward or even to normal; if dosed appropriately, GH therapy has few adverse effects. Although some doubts remain about possible long-term risks of childhood GH therapy, most registries of adult GH replacement therapy, albeit limited in study size and duration, have not shown an increased incidence of cancers or of cardiovascular morbidity or mortality.

译文

自 1980 以来，潜在无限量的合成重组人生长激素 (GH) 的可用性提高了人们对 GH 对新陈代谢、身体组成、身体和心理功能的许多无状态影响的理解, 以及成人生活中生长激素缺乏的后果。成人生长激素缺乏现在被认为是一种独特的非特异性综合征，具有相当大的不良健康后果。与儿童相比，较低剂量的生长激素替代疗法可以逆转许多这些异常，恢复功能能力，甚至恢复正常; 如果剂量适当，生长激素治疗几乎没有副作用。尽管对儿童生长激素治疗可能的长期风险仍有一些疑问，但大多数成人生长激素替代治疗的注册，尽管研究规模和持续时间有限, 没有显示癌症或心血管疾病发病率或死亡率的增加。