摘要

The availability of synthetic recombinant human growth hormone (GH) in potentially unlimited quantities since the 1980s has improved understanding of the many nonstatural effects of GH on metabolism, body composition, physical and psychological function, as well as the consequences of GH deficiency in adult life. Adult GH deficiency is now recognized as a distinct if nonspecific syndrome with considerable adverse health consequences. GH replacement therapy in lower doses than those used in children can reverse many of these abnormalities and restore functional capacities toward or even to normal; if dosed appropriately, GH therapy has few adverse effects. Although some doubts remain about possible long-term risks of childhood GH therapy, most registries of adult GH replacement therapy, albeit limited in study size and duration, have not shown an increased incidence of cancers or of cardiovascular morbidity or mortality.

译文

自 1980 以来,潜在无限量的合成重组人生长激素 (GH) 的可用性提高了人们对 GH 对新陈代谢、身体组成、身体和心理功能的许多无状态影响的理解, 以及成人生活中生长激素缺乏的后果。成人生长激素缺乏现在被认为是一种独特的非特异性综合征,具有相当大的不良健康后果。与儿童相比,较低剂量的生长激素替代疗法可以逆转许多这些异常,恢复功能能力,甚至恢复正常; 如果剂量适当,生长激素治疗几乎没有副作用。尽管对儿童生长激素治疗可能的长期风险仍有一些疑问,但大多数成人生长激素替代治疗的注册,尽管研究规模和持续时间有限, 没有显示癌症或心血管疾病发病率或死亡率的增加。

Growth hormone deficiency

儿科 生长发育障碍性疾病 疾病
概述  :  

生长激素缺乏症(GHD)是指由于垂体前叶合成和分泌生长激素部分或完全缺乏,或由于其结构异常、受体缺陷等所致的生长发育障碍性疾病。生长激素的生理功能生长激素(HGH)是大脑下丘脑-垂体前叶分泌的能促进身体生长的一种肽类激素,对肝脏和其它组织,以刺激生产的胰岛素样生长因子(IGF-I)发挥其生理功能,促进骨骼生长,蛋白质合成,加速脂肪,肌肉组织增加。正常情况下,生长激素(HGH)呈脉冲式分泌,生长激素(HGH)的分泌受下丘脑产生的生长激素释放素(GHRH)和生长激素抑制激素(GHIH,也称生长抑

growth 英 /ɡrəʊθ/  美 /ɡroʊθ/

释    义   n. 增长;发展;生长;种植

例    句   The research areas cover diabetes, obesity, growth hormone deficiency and haemophilia. 研发领域覆盖糖尿病,肥胖症,生长激素缺乏症及血友病等疾病。

 

hormone 英 /ˈhɔːməʊn/  美 /ˈhɔːrmoʊn/

释    义   n. [生理] 激素,荷尔蒙

例    句   Androgen deficiency causes long Bones to continue growing after they would normally stop. Overproduction of growth hormone-usually due to a tumour-causes pituitary gigantism (see pituitary gland). 雄激素缺乏会造成原本应停止成长的长骨骨继续成长。生长激素分泌过多--通常是肿瘤所致--会导致脑下垂体性巨人症。

 

deficiency 英 /dɪˈfɪʃnsi/  美 /dɪˈfɪʃnsi/

释    义   n. 缺陷,缺点;缺乏;不足的数额

例    句   The study looked at patients treated during childhood for growth hormone deficiency or shortstature of unknown cause. 这个研究着眼于那些在儿童期因生长激素缺乏或者不明原因的身材短小而接受治疗的患者。

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