摘要

BACKGROUND:Hypothermia therapy improves mortality and functional outcome after cardiac arrest and birth asphyxia in adults and newborns. The effect of hypothermia therapy in infants and children with cardiac arrest is unknown.
METHODS AND RESULTS:A 2-year, retrospective, 5-center study was conducted, and 222 patients with cardiac arrest were identified. Seventy-nine (35.6%) of these patients met eligibility criteria for the study (age >40 weeks postconception and 3 minutes in duration, survival for > or = 12 hours after return of circulation, and no birth asphyxia). Twenty-nine (36.7%) of these 79 patients received hypothermia therapy and were cooled to 33.7+/-1.3 degrees C for 20.8+/-11.9 hours. Hypothermia therapy was associated with higher mortality (P=0.009), greater duration of cardiac arrest (P=0.005), more resuscitative interventions (P

译文

背景: 低温治疗可改善成人和新生儿心脏骤停和出生窒息后的死亡率和功能结果。低温疗法对心脏骤停的婴儿和儿童的影响尚不清楚。
方法和结果: 进行了一项为期 2 年、回顾性、 5 个中心的研究,确定了 222 名心脏骤停患者。这些患者中有 79 名 (35.6%) 符合该研究的合格标准 (年龄> 40 周后受孕,持续 3 分钟,在循环恢复后存活> 或 = 12 小时, 并且没有出生窒息)。这 79 名患者中有 29 名 (36.7%) 接受了低温治疗,并将其冷却至 33.7/-1.3 摄氏度,持续 20.8/-11.9 小时。低温治疗与更高的死亡率 (P = 0.009) 、更长的心脏骤停持续时间 (P = 0.005) 、更多的复苏干预 (P

Hypothermia therapy

儿科 脑损伤治疗 治疗方法
概述  :  

目前国际医学界将治疗性低温划分为轻度低温(33~35℃)、中度低温(28~32℃)、深度低温(17~ 27℃)、超深度低温(≤16℃),将轻中度低温(28~35℃) 称为亚低温。亚低温治疗机制研究显示,亚低温疗法对脑损伤的保护机制是通过多种途径实现的。亚低温治疗首先使脑细胞的需氧量减少,降低脑氧代谢率。数据显示,体温每降低1℃(在诱导低温过程中),脑细胞代谢率下降5%~7%。相关研究证实了在脑损伤的初期阶段,亚低温治疗可有效改善脑细胞损害,其作用是通过阻断脑细胞凋亡、抑制线粒体损伤作用、减轻

hypothermia  英/,haɪpə(ʊ)'θɜːmɪə/ 美 /,haɪpə'θɝmɪə/

释    义   n. 降低体温;低体温症

例    句   The operation was performed under deep hypothermia and extracorporeal circulation with low flow perfusion. 手术采用胸骨正中切口在体外循环深低温低流量灌注下施行。

 

therapy  英 /'θerəpɪ/  美 /'θɛrəpi/

释    义   n. 治疗,疗法

例    句   One of the not so noticed areas of rehabilitation medicine is Speech Therapy. 其中的并非如此注意到领域的康复医学是言语治疗。

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