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Immune thrombocytopenia

儿科

关键词儿科 疾病 血液

词汇介绍

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解析

immune 英 /ɪˈmjuːn/  美 /ɪˈmjuːn/

释    义   n. 免疫者;免除者     

adj. 免疫的;免于……的,免除的

例    句   Once this happens, you have an organ in your body that maintains and anchors your entireimmune system. 一旦这发生了,你们具有身体里的维持和锚定整个免疫系统的一器官。

 

thrombocytopenia 英 /,θrɒmbə(ʊ),saɪtə(ʊ)'piːnɪə/ 美 /,θrɑmbə,saɪtə'piniə/

释    义   n. [内科] 血小板减少(症)

例    句   Thrombocytopenia is one of the most common bleeding disorders of animals. 血小板减少症是动物最常见的出血性疾病之一。

概述

原发免疫性血小板减少症(ITP),既往亦称为特发性血小板减少性紫癜,是一种获得性自身免疫性、出血性疾病,儿童年发病率约为 4-5/10万,高于成人患者。部分患儿仅有血小板减少,没有出血症状;部分患儿可有明显的乏力症状;威胁生命的严重出血少见,如颅内出血的发生率<1%。临床表现在建康儿童身上发生单纯血小板计数减少(血小板形态、功能无异常)以及与之有关的临床出血表现。仅有与血小板减少相关的出血表现:以皮肤和粘膜出血多见,表现为紫癜、瘀斑、鼻衄、齿龈出血,消化道出血和血尿。偶有颅内出血,是引起死亡

T cell receptor grafting allows virological control of Hepatitis B virus infection复制标题

T细胞受体移植术允许病毒学控制乙型肝炎病毒感染

发表时间:2019-04-30

影响因子:12.3

作者: Wisskirchen Karin

期刊:J Clin Invest

Although the incidence of severe fever with thrombocytopenia syndrome virus (SFTSV) infection has increased from its discovery with a mortality rate of 10-20%, no effective vaccines are currently available. Here we describe the development of a SFTSV DNA vaccine, its immunogenicity, and its protective efficacy. Vaccine candidates induce both a neutralizing antibody response and multifunctional SFTSV-specific T cell response in mice and ferrets. When the vaccine efficacy is investigated in aged-ferrets that recapitulate fatal clinical symptoms, vaccinated ferrets are completely protected from lethal SFTSV challenge without developing any clinical signs. A serum transfer study reveals that anti-envelope antibodies play an important role in protective immunity. Our results suggest that Gn/Gc may be the most effective antigens for inducing protective immunity and non-envelope-specific T cell responses also can contribute to protection against SFTSV infection. This study provides important insights into the development of an effective vaccine, as well as corresponding immune parameters, to control SFTSV infection.

译文

虽然严重发热伴血小板减少综合征病毒(sftsv)感染的发病率已从发现时的10-20%上升,但目前还没有有效的疫苗。本文介绍了一种sftsv-dna疫苗的研制、免疫原性和保护作用。候选疫苗在小鼠和雪貂体内诱导中和抗体反应和多功能sftsv特异性t细胞反应。当对重现致命临床症状的老年雪貂进行疫苗效力调查时,接种过疫苗的雪貂完全免受致命SFTSV攻击,而不会出现任何临床症状。血清转移研究表明,抗包膜抗体在保护性免疫中起重要作用。我们的结果表明,gn/gc可能是诱导保护性免疫的最有效抗原,非包膜特异性t细胞反应也有助于保护sftsv感染。这项研究为开发一种有效的疫苗以及相应的免疫参数以控制sftsv感染提供了重要的见解。