hemolytic 英 /hi:'mɔlitik/ 美 /hi:'mɔlitik/
释 义 adj. [生理][免疫] 溶血的
例 句 To compare the prediction effect on hemolytic disease of the newborn between monocyte monolayer assay and antibody titre. 目的应用单核细胞单层试验和抗体效价测定试验预判新生儿溶血病的效果比较。
uremic 英 /ju'ri:mik/ 美 /ju'ri:mik/
释 义 adj. [泌尿] 尿毒症的
例 句 There are abnormal changes of coagulation and fibrinolysis system in uremic patients with chronic renal failure, which are increased during hemodialysis. 尿毒症患者存在着凝血与纤溶系统的异常改变，血液透析可以使这种变化更加明显。
作者： Arimizu Yoko
How pathogens evolve their virulence to humans in nature is a scientific issue of great medical and biological importance. Shiga toxin (Stx)-producing (STEC) and enteropathogenic (EPEC) are the major foodborne pathogens that can cause hemolytic uremic syndrome and infantile diarrhea, respectively. The locus of enterocyte effacement (LEE)-encoded type 3 secretion system (T3SS) is the major virulence determinant of EPEC and is also possessed by major STEC lineages. Cattle are thought to be the primary reservoir of STEC and EPEC. However, genome sequences of bovine commensal are limited, and the emerging process of STEC and EPEC is largely unknown. Here, we performed a large-scale genomic comparison of bovine commensal with human commensal and clinical strains, including EPEC and STEC, at a global level. The analyses identified two distinct lineages, in which bovine and human commensal strains are enriched, respectively, and revealed that STEC and EPEC strains have emerged in multiple sublineages of the bovine-associated lineage.