摘要

Thunqvist and colleagues reported that pulmonary function testing using spirometry and oscillometry 6.5 years after pre-term birth at 22- 26 weeks EGA showed increased bronchore activity to β-agonist treatment along with impaired FVC and FEV1.The authors reported that nearly all their subjects were diagnosed with BPD, which likely affected the magnitude of impaired pulmonary function. As expected, the severity of BPD correlated with the severity of impairment. Lo and colleagues reported parallel decrements of FRC in survivors of preterm birth at 26 weeks that were measured by plethysmography and Hedilution at age 1 year and age 11-14 years. The superimposition of rapid weight gain may also contribute in this setting. Lowe and colleagues correlated high rates of fetal and infant growth among the prematurely born with postnatally reported wheezing. The effect was further worsened by maternal smoking.Jackson and colleagues analyzed data from the multi-center ELGAN study to identify risk factors for BPD and correlations with parent reported asthma in those study subjects. They found that growth restriction and gestational age affected BPD risk, but that BPD only predicted bronchodilator use at 1 and 2 years, not asthma at 10 years. As others have shown, the wheezing in patients with BPD is not allergic asthma: wheezing may be driven by abnormal airway structural development. We know that effects of BPD and prematurity on airway resistance and FRC are long-standing, but this does not appear to be the same as increasing the risk for allergic asthma. Along with other reports, the authors found that weight gain velocity during infancy also increased the risk for asthma along with maternal SES, another example of disturbed developmental programming.

译文

Thunqvist及其同事报道,在EGA 22-26周早产后6。5年使用肺活量测定法和示波法进行的肺功能测试显示,对于β-激动剂治疗,支气管活性增加,同时FVC和FEV1受损。作者报告说他们几乎所有的受试者都是诊断为BPD,可能影响肺功能受损的程度。正如预期的那样,BPD的严重程度与损伤的严重程度相关。 Lo及其同事报道,26周时早产幸存者的FRC平行下降,通过体积描记法和1岁时和11-14岁的Hedilution测量。快速增重的叠加也可能有助于此设置。 Lowe及其同事将过早出生的胎儿和婴儿生长率与出生后报告的喘息相关联。母亲吸烟会进一步恶化这种影响。Jackson及其同事分析了来自多中心ELGAN研究的数据,以确定BPD的风险因素以及与这些研究对象中父母报告的哮喘的相关性。他们发现生长受限和孕龄会影响BPD风险,但BPD仅预测1年和2年使用支气管扩张剂,而不是10年时的哮喘。正如其他人所表明的那样,BPD患者的喘息不是过敏性哮喘:喘息可能是由异常的气道结构发展引起的。我们知道BPD和早产对气道阻力和FRC的影响是长期存在的,但这似乎与增加过敏性哮喘的风险并不相同。与其他报道一起,作者发现,婴儿期体重增加速度也增加了哮喘风险以及母体SES,这是另一个受干扰的发育规划的例子。

Neonatal Respiratory Distress Syndrome

儿科 呼吸系统疾病 疾病
概述  :  

新生儿呼吸窘迫综合征(NRDS)是由于肺表面活性物质(PS)缺乏而引起的导致新生儿呼吸衰竭甚至死亡的呼吸系统疾病,以前普遍认为 RDS 主要发生于早产儿,然而随着早产儿分娩前使用糖皮质激素促进肺发育成熟以及出生后PS的有效使用,使得早产儿RDS的治疗率及存活率不断提高。NRDS 的治疗主要为呼吸支持及对症治疗。病因及临床意义新生儿呼吸窘迫综合征是由于各种原因引起肺表面活性物质缺乏或异常,导致进行性肺不张,严重时可引起呼吸衰竭。PS 缺乏或结构不成熟是导致此病的重要原因,病理上由于肺泡壁至终末

neonatal  英 /,niːə(ʊ)'neɪt(ə)l/  美 /,nio'netl/

       adj. 新生的;初生的

       Jaundice in adults and older children is not related to neonatal jaundice; it is usually the sign of a health problem. 黄疸在成人和年龄较大的儿童是不相关的新生儿黄疸,这是通常的迹象是一个健康问题。

 

respiratory  英 /rɪˈspɪrət(ə)ri/  美 /ˈrɛspərəˌtɔri/

       adj. 呼吸的

       The study in the European Respiratory Journal zinked this with weight gain and pressure on the lungs and trachea caused by the distended abdomen. 该项发表于《欧洲呼吸期刊》的研究认为,此与体重增加,以及肺部和气管受到腹部膨胀造成的压力有关。

 

distress  英 /dɪ'stres/  美 /dɪ'strɛs/

       n. 危难,不幸;贫困;悲痛

vt. 使悲痛;使贫困

       Many individuals are more apt to seek informal support from family and friends, which may not be sufficient to prevent long-term distress for some. 许多人还是更加倾向于从家人和朋友处寻求支持,而这些支持对某些人来说并不足以抵抗长期的痛苦。

 

syndrome  英 /'sɪndrəʊm/  美 /'sɪndrəm/

       n. [临床] 综合症状;并发症状;校验子;并发位

       Women complain about premenstrual syndrome, but I think of it as the only time of the month that I can be myself. 女人会抱怨经前期综合症,但是我认为这是一个月中我唯一可以做回我自己的日子。

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