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首页 > 医学词汇大全 > Neonatal Apnea
Neonatal Apnea

儿科

关键词儿科 临床研究术语 新生儿疾病

词汇介绍

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解析

neonatal /,niːə(ʊ)'neɪt(ə)l/  /,nio'netl/

       adj. 新生的;初生的

       Neonatal neurons can migrate into the areas of the infarction, substituting some dead neurons. 新生的神经元还可以迁移到病灶区替代一部分死亡的神经元。

 

apnea  /æp'nɪə/  /æp'niə/

       n. [] 窒息,[临床] 呼吸暂停

       For example, patients with hypertension, high blood pressure and some patients are at night or during the morning high blood pressure because blood pressure at night of sleep apnea causes the disease. 比如说高血压病人,有的病人都是夜里血压高,或者早晨起来时血压高,这是因为夜里睡眠呼吸暂停引起血压病的原因。

概述

 新生儿呼吸暂停即为新生儿在一段时间之内无呼吸运动,其在早产儿人群中属于较为常见的一种疾病。新生儿呼吸暂停属于新生儿科当中较为常见的一种危重症,其可对新生儿的机体产生极大的危害,且可严重威胁新生儿的生存质量甚至生命安全。 病因及临床意义 目前临床将新生儿呼吸暂停分为原发性与继发性两种,其中原发性呼吸暂停即为新生儿在未有任何原发因素的基础上出现呼吸暂停症状,该症状的发生同新生儿的胎龄及出生体重有密切关联。继发性呼吸暂停即为受各种不同基础疾病影响出 现的呼吸暂停症状

Caffeine exposure and acute kidney injury in premature infants with necrotizing enterocolitis and spontaneous intestinal perforation复制标题

坏死性小肠结肠炎和自发性肠穿孔早产儿咖啡因暴露与急性肾损伤

发表时间:2018-11-06

影响因子:2.8

作者: Noelia Aviles-Otero

期刊:Pediatr Nephrol

Fifth, our study simultaneously evaluated patients with both NEC and SIP. This limits the ability to determine the role of AKI in each disease process specifically. While NEC and SIP are pathologically distinct conditions, in clinical practice, it may be difficult to distinguish between them with certainty using current classification schema. Moreover, we feel that both of these conditions provide a suitable pathophysiologic model for AKI. Finally, this study considered only patients with NEC/SIP; healthy controls were not included. It cannot be determined from this study whether exposure to caffeine might increase the likelihood of developing NEC or SIP, or alter the natural history of either disease when it occurs. Some small studies have suggested a direct association between caffeine exposure and NEC and an inverse relationship with SIP. However, large randomized controlled trials found no difference in the occurrence of these conditions among patients receiving caffeine versus placebo. Exposure to caffeine in preterm infants with NEC or SIP is associated with decreased incidence and severity of AKI. These data are consistent with other recent studies in the general NICU population and suggest potential utility of caffeine in preventing AKI. Further studies are needed to delineate optimal timing and dosing of caffeine to maximize its benefits.

译文

第五,我们的研究同时评估了NEC和SIP患者。这限制了确定AKI在每个疾病过程中的作用的能力。虽然NEC和SIP在病理学上是不同的,但在临床实践中,使用当前的分类方案可能难以确定地区分它们。此外,我们认为这两种情况都为AKI提供了合适的病理生理学模型。最后,本研究仅考虑了NEC / SIP患者;健康对照不包括在内。从这项研究中无法确定接触咖啡因是否会增加发生NEC或SIP的可能性,或改变任何一种疾病发生时的自然病史。一些小型研究表明,咖啡因暴露与NEC之间存在直接关联,与SIP呈反比关系。然而,大型随机对照试验发现接受咖啡因与安慰剂的患者中这些病症的发生率没有差异。NEC或SIP早产儿接触咖啡因与AKI发生率和严重程度降低有关。这些数据与一般NICU人群中的其他近期研究一致,并提示咖啡因在预防AKI方面的潜在用途。需要进一步研究以描绘咖啡因的最佳时间和剂量以最大化其益处。