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首页 > 医学词汇大全 > Chlamydial Infection
Chlamydial Infection

儿科

关键词儿科 疾病 衣原体感染

词汇介绍

拓展阅读

解析

chlamydial  /kləˈmɪdɪəl/

       adj. 衣原体的

       For example, 10 - 40% of women with untreated chlamydial infection develop symptomatic pelvic inflammatory disease. 在沙眼衣原体感染未得到治疗的女性中,有10-40%的人发展为症状性盆腔炎症。

 

infection  /ɪn'fekʃ(ə)n/  /ɪn'fɛkʃən/

       n. 感染;传染;影响;传染病

       In women chlamydial infection is one of the principal causes of Pelvic inflammatory disease.  在妇女沙眼衣原体感染是其中一个主要的原因,盆腔炎的。

概述

 新生儿衣原体感染是由沙眼衣原体(CT)引起。衣原体是必须在活细胞内生活、增殖的一类独立微生物群,其中与新生儿感染有关的主要是CT。本病主要通过性传播,是发达国家最常见的性传播疾病。新生儿CT感染主要是在分娩时通过产道获得,剖宫产出生的婴儿受感染的可能性很小,多由胎膜早破病原体上行而致。 临床表现 ① 衣原体结膜炎:是新生儿期结膜炎中最常见的病原菌,暴露于病原体者有1/3发病,潜伏期通常为5-14天,很少超过19天。胎膜早破患儿可更早出现结膜炎。分泌

Host-Pathogen Interactions during Female Genital Tract Infections复制标题

女性生殖道感染期间宿主-病原体相互作用

发表时间:2019-08-23

影响因子:12.0

作者: Pekmezovic Marina

期刊:Trends Microbiol

FGT pathogens are constantly interacting with other members of the microbiota. A substantial number of synergistic or antagonistic associations have been described for different microbial partners in different niches; however, not much is known for the FGT environment. Besides the competition for the same spatial and nutritional resources, recent data show that such interactions could play an important role in cocolonizations or coinfections. In some cases, FGT pathogens can take advantage of others and ensure their survival. For example, C. trachomatis is a tryptophan auxotroph and relies on host sources which are limited due to a protective effect of human interferon gamma (IFNγ) via tryptophan catabolism. However, IFNγ exposure induces an upregulation of chlamydial genes that can synthesize tryptophan through indole salvage. This salvage pathway is possible during coinfections since other FGT pathogens (such as Prevotella spp., Clostridiales and T. vaginalis) can express a functional tryptophanase to produce indole from tryptophan.

译文

FGT病原体不断与微生物群的其他成员相互作用。已经针对不同生态位中的不同微生物伴侣描述了大量的协同或拮抗关联;然而,对FGT环境知之甚少。除了对相同空间和营养资源的竞争之外,最近的数据表明这种相互作用可能在结构化或共感染中起重要作用。在某些情况下,FGT病原体可以利用其他病原体并确保其存活。例如,沙眼衣原体是色氨酸营养缺陷型并且依赖于宿主来源,其由于人干扰素γ(IFNγ)通过色氨酸分解代谢的保护作用而受到限制。然而,IFNγ暴露诱导衣原体基因的上调,其可以通过吲哚补救来合成色氨酸。由于其他FGT病原体(例如Prevotella spp。,Clostridiales和T. vaginalis)可以表达功能性色氨酸酶以从色氨酸产生吲哚,因此这种补救途径在合并期间是可能的。