首页 > 医学词汇大全 > Toxoplasmosis
Toxoplasmosis

儿科

关键词儿科 疾病 寄生虫感染

词汇介绍

拓展阅读

解析

toxoplasmosis   /,tɒksəʊplæz'məʊsɪs/  /,tɑksoplæz'mosɪs/

       n. [内科] 弓形体病,弓浆虫病

       Cats can carry a disease called toxoplasmosis, which can be contracted by coming into contact with their waste products. 猫携带一种被称作弓浆虫病的疾病,可能因为接触他们的排泄物而感染。

概述

 弓形虫病是由刚地弓形虫引起的人畜共患病。该病原广泛存在于自然界,几乎所有哺乳动物和人及某些鸟类都是中间宿主,猫科动物是其唯一的终宿主。成人弓形虫感染大多为亚临床感染。经胎盘传播引起胎儿先天性弓形虫感染者,其孕母几乎均为原发性感染,母亲慢性感染引起的先天性感染罕见,弓形虫病经胎盘传播率约为40%,且传播率随胎龄增大而增加,但胎儿感染严重程度随胎龄增大而减轻。 传播途径 ①经食物传染;②猫粪传染;③土壤污染和昆虫机械传染;④先天性感染。 临床表现&nb

Toxoplasma gondii ROP16 kinase silences the cyclin B1 gene promoter by hijacking host cell UHRF1-dependent epigenetic pathways复制标题

弓形虫ROP16激酶通过劫持宿主细胞UHRF1-dependent表观遗传途径沉默细胞周期蛋白B1基因启动子

发表时间:2019-09-06

影响因子:7.0

作者: Sabou Marcela

期刊:Cell Mol Life Sci

Toxoplasmosis, caused by the apicomplexan parasite Toxoplasma gondii, is one of the most common infections in the world due to the lifelong persistence of this parasite in a latent stage. This parasite hijacks host signaling pathways through epigenetic mechanisms which converge on key nuclear proteins. Here, we report a new parasite persistence strategy involving T. gondii rhoptry protein ROP16 secreted early during invasion, which targets the transcription factor UHRF1 (ubiquitin-like containing PHD and RING fingers domain 1), and leads to host cell cycle arrest. This is mediated by DNMT activity and chromatin remodeling at the cyclin B1 gene promoter through recruitment of phosphorylated UHRF1 associated with a repressive multienzymatic protein complex. This leads to deacetylation and methylation of histone H3 surrounding the cyclin B1 promoter to epigenetically silence its transcriptional activity. Moreover, T. gondii infection causes DNA hypermethylation in its host cell, by upregulation of DNMTs.

译文

由顶复门寄生虫弓形虫引起的弓形虫病是世界上最常见的感染之一,因为该寄生虫在潜伏期终生持久存在。这种寄生虫通过表观遗传机制劫持宿主信号传导途径,这些机制会聚在关键的核蛋白上。在这里,我们报告了一种新的寄生虫持续性策略,该策略涉及在入侵早期分泌的弓形虫rhoptry蛋白ROP16,其靶向转录因子UHRF1(含有PHD和环状结构域1的遍在蛋白样),并导致宿主细胞周期停滞。这是通过DNMT活性和细胞周期蛋白B1基因启动子的染色质重塑介导的,通过募集与抑制性多酶蛋白复合物相关的磷酸化UHRF1。这导致细胞周期蛋白B1启动子周围的组蛋白H3的去乙酰化和甲基化,以表观遗传地沉默其转录活性。此外,弓形虫感染通过上调DNMT在其宿主细胞中引起DNA高甲基化。