toxoplasmosis 英 /,tɒksəʊplæz'məʊsɪs/ 美 /,tɑksoplæz'mosɪs/
释 义 n. [内科] 弓形体病，弓浆虫病
例 句 Cats can carry a disease called toxoplasmosis, which can be contracted by coming into contact with their waste products. 猫携带一种被称作弓浆虫病的疾病，可能因为接触他们的排泄物而感染。
作者： Sabou Marcela
期刊：Cell Mol Life Sci
Toxoplasmosis, caused by the apicomplexan parasite Toxoplasma gondii, is one of the most common infections in the world due to the lifelong persistence of this parasite in a latent stage. This parasite hijacks host signaling pathways through epigenetic mechanisms which converge on key nuclear proteins. Here, we report a new parasite persistence strategy involving T. gondii rhoptry protein ROP16 secreted early during invasion, which targets the transcription factor UHRF1 (ubiquitin-like containing PHD and RING fingers domain 1), and leads to host cell cycle arrest. This is mediated by DNMT activity and chromatin remodeling at the cyclin B1 gene promoter through recruitment of phosphorylated UHRF1 associated with a repressive multienzymatic protein complex. This leads to deacetylation and methylation of histone H3 surrounding the cyclin B1 promoter to epigenetically silence its transcriptional activity. Moreover, T. gondii infection causes DNA hypermethylation in its host cell, by upregulation of DNMTs.