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Cytomegalovirus infection

儿科

关键词儿科 临床研究术语 病毒感染

词汇介绍

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解析

cytomegalovirus /,saɪtə(ʊ)'meg(ə)lə(ʊ),vaɪrəs/  /,saɪto'mɛɡəlovaɪrəs/

       n. [病毒] 巨细胞病毒

同根词   cytokinesis n. [细胞] 胞质分裂;细胞浆移动

cytology n. 细胞学

cytogenetics n. 细胞遗传学

       Cytomegalovirus is one of the five known herpes viruses that infect humans. 巨细胞是人类所接触到的五类疱疹病毒之一。 

 

infection  /ɪn'fekʃ(ə)n/   /ɪn'fɛkʃən/

       n. 感染;传染;影响;传染病

       Their intention was to encourage those patient’s immune systems to attack the tumours by trainingthem to recognise the signs of active cytomegalovirus infection. 他们的打算是通过训练病人免疫系统来识别活跃的巨细胞病毒感染的特征来达到促使免疫系统攻击肿瘤的目的。

概述

 人巨细胞病毒(HCMV)是最常见的先天性感染之一,呈全球性分布,在全球活产婴儿中HCMV先天性感染率约为0.7%,是新生儿罹患先天性感音神经性耳聋、视力障碍、智力发育迟缓和病毒性肝炎、病毒性肺炎等疾病的常见原因,严重者可导致流产、死胎、早产和新生儿死亡。 HCMV感染分类   (1)原发感染:指初次感染HCMV,在被感染前缺乏HCMV-IgG抗体,在感染后出现HCMV-IgG抗体转化。(2)复发感染:由潜伏在人体内的HCMV再激活引起的感染。(3)再

Hearing Loss With Congenital Cytomegalovirus Infection复制标题

先天性巨细胞病毒细胞病毒感染的听力损失

发表时间:2019-07-19

影响因子:5.4

作者: Foulon Ina

期刊:Pediatrics

Congenital cytomegalovirus (cCMV) infection is the most common fetal viral infection and is the leading cause of nonhereditary sensorineural hearing loss (SNHL) in the developed world.1 Despite the high incidence of cCMV infection (0.53%), screening for a cytomegalovirus infection during pregnancy and neonatal screening at birth are not recommended. However, asymptomatic children can develop sequelae, with SNHL as the most present feature. The risk of developing hearing loss in children with an asymptomatic infection is between 5% and 20%.1,4–6 In ∼10% of the children, the infection is symptomatic at birth. The risk for developing SNHL in those symptomatic children is much higher (30%–65%).4–7 In this prospective study, we determined the incidence of SNHL in 157 children with proven cCMV infection. We searched for risk determinants for developing hearing loss and propose recommendations for screening and follow-up in the newborn.

译文

先天性巨细胞病毒(cCMV)感染是最常见的胎儿病毒感染,是发达国家非遗传性感音神经性耳聋(SNHL)的主要原因.1尽管cCMV感染发生率很高(0.53%),但筛查巨细胞病毒感染期间 不建议在出生时进行怀孕和新生儿筛查。 然而,无症状的儿童可能会出现后遗症,其中SNHL是最具特色的。 无症状感染儿童听力损失的风险在5%到20%之间.1,4-6在~10%的儿童中,感染是出生时的症状。 在这些有症状的儿童中发生SNHL的风险要高得多(30%-65%)。4-7在这项前瞻性研究中,我们确定了157名已证实为cCMV感染的儿童的SNHL发病率。 我们搜索了发生听力损失的风险决定因素,并提出了新生儿筛查和随访的建议。