微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Nephrotic Syndrome
Nephrotic Syndrome

儿科

关键词儿科 疾病 1

词汇介绍

拓展阅读

解析

nephrotic    /ni'frɔtik/   /ni'frɔtik/

       adj. [泌尿] 肾病的;肾病变的

      edema nephrotic 肾病性水肿      

nephrotic type 肾病型      

nephrotic children 肾病小儿

       Nephrotic syndrome is usually caused by damage to the clusters of small blood vessels in your kidneys that filter waste and excess water from your blood. 肾病综合症一般是由肾小球(肾脏里面的小血管簇,可以滤过血液内的废物和多余水分)的损害引起的。 

 

syndrome    /'sɪndrəʊm/   /'sɪndrəm/

       n. [临床] 综合症状;并发症状;校验子;并发位

      Down syndrome 唐氏综合症

Turner syndrome 特纳氏综合症

hypereosinophilic syndrome 嗜酸性粒细胞增多症

       Diagnosis and treatment of patient with sleep apnea syndrome睡眠呼吸暂停综合症的诊断和治疗

概述

肾病综合征是儿科常见肾内科疾病,临床表现为大量蛋白尿、低蛋白血症、高胆固醇血症及水肿,根据其对糖皮质激素治疗的效果可分为激素敏感型、激素依赖型及激素耐药。肾病综合征又可根据类型分为原发性、继发性和先天性NS 3种类型,而原发性NS约占小儿时期NS总数的90%,是儿童常见的肾小球疾病之一。发病机制肾病综合征关键性的改变是肾小球毛细血管壁的损伤,血浆蛋白滤过增加,形成大量蛋白尿。滤过膜损伤较轻时,尿中主要为低分子量的白蛋白和转铁蛋白(选择性蛋白尿);损伤严重时大分子量的蛋白也可滤过,形成非选择

Response to combined ipilimumab and nivolumab after development of a nephrotic syndrome related to PD-1 monotherapy.复制标题

与PD-1单药治疗相关的肾病综合征发生后对ipilimumab和nivolumab联合治疗的反应。

发表时间:2019-07-12

影响因子:8.7

作者: Glutsch Valerie

期刊:J Immunother Cancer

The frequency of renal adverse events related to anti-PD-1 therapy is very low. Interstitial nephritis with predominant tubulointerstitial injury is the most common presentation of an acute kidney injury related to anti-PD-1 therapy, whereas an acute renal failure with nephrotic syndrome due to a minimal change disease is rare. So far, only two cases of nephrotic syndrome with minimal change disease secondary to therapy with an anti-PD-1 antibody have been reported. Both patients received pembrolizumab for Hodgkin’s lymphoma (HL). In contrast to HL, malignant melanoma is not known to induce minimal change disease itself. Thus, the acute kidney injury in our patient was related to pembrolizumab most likely. Consistent with the two cases reported and guidelines for managing irAE, immunotherapy was stopped and both creatinine as well as proteinuria improved after administering systemic glucocorticoids.

译文

与抗PD-1治疗相关的肾脏不良事件的发生率非常低。 具有显着的肾小管间质损伤的间质性肾炎是与抗PD-1疗法相关的急性肾损伤的最常见表现,而由于微小变化疾病导致的肾病综合征的急性肾衰竭是罕见的。 到目前为止,仅有两例肾病综合征患者继发抗PD-1抗体治疗后发生微小病变。 两名患者均接受了pembrolizumab治疗霍奇金淋巴瘤(HL)。 与HL相反,不知道恶性黑素瘤本身会诱发微小的变化疾病。 因此,我们患者的急性肾损伤最可能与pembrolizumab有关。 与报告的两例病例和管理irAE的指南一致,停止免疫治疗,并且在给予全身性糖皮质激素后肌酐和蛋白尿均得到改善。