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首页 > 医学词汇大全 > Kawasaki Disease
Kawasaki Disease

儿科

关键词儿科 疾病 临床疾病

词汇介绍

拓展阅读

解析

Kawasaki   英 /,kɑ:wə'sɑki/ 

         n. 川崎

          Kawasaki disease is now a major reason for acquired heart disease in children, but its etiology and pathophysiological mechanism are unknown. 川崎病是目前儿童后天性心脏病的主要病因之一,但是其病因不明,临床研究其发病机制存在诸多限制。


Disease     英 /dɪ'ziːz/  美 /dɪ'ziz/

         n. 病,[医] 疾病;弊病 

vt. 传染;使…有病

          No special treatment is needed for the lung lesion, which can recover with the systemic therapy of Kawasaki disease. 肺部病变无需特殊治疗,可随着川崎病的系统治疗而恢复。

概述

川崎病(KD)又称为黏膜皮肤淋巴结综合征,是儿童期最常见的血管炎之一,主要发生于5岁以下儿童,成人极少发生川崎病。川崎病通常为自限性疾病,在没有治疗的情况下发热及急性炎症的表现平均持续11日。但是川崎病常可能发生一些并发症,提高了此病的致死率。 病理改变川崎病血管病变主要累及肌性动脉,并以坏死性动脉炎、亚急性/慢性血管炎、血管内肌纤维母细胞增生(LMP)为特征病变。大型或巨型冠状动脉瘤的直径≥8 mm或Z评分≥10时,不需处理,它们很少破裂,一般含有血栓,易致血管堵塞。动脉瘤明显

Early childhood exposure to maternal smoking and Kawasaki Disease: A longitudinal survey in Japan复制标题

母亲吸烟和川崎病的儿童早期暴露: 日本的一项纵向调查

发表时间:2019-03-10

影响因子:5.6

作者: Takashi Yorifuji

期刊:Sci Total Environ

Kawasaki disease (KD) is a systemic vasculitis that affects mediumsize arteries and is the leading cause of acquired childhood heart disease in most developed countries. Approximately 20–25% of untreated children present with coronary artery abnormalities including aneurysms. KD is seen in children worldwide, but its incidence is highest in Japan and is increasing, posing a growing threat to children's health. The etiology of the disease is, however, unknown; an aberrant immune response to some environmental triggers is considered to play a role among genetically-predisposed children. One potential cause of the disease is involuntary exposure to tobacco smoke (secondhand smoke); it has been estimated that 40% of children are exposed to secondhand smoke worldwide.

译文

川崎病是一种影响中动脉的全身性血管炎,是大多数发达国家儿童获得性心脏病的主要病因。约20-25%未经治疗的儿童出现冠状动脉异常,包括动脉瘤。在全世界的儿童中都发现了KD,但其发病率在日本最高,而且还在增加,对儿童健康构成了越来越大的威胁。然而,该疾病的病因尚不清楚;对某些环境因素的异常免疫反应被认为在遗传易感儿童中起作用。该病的一个潜在原因是非自愿接触烟草烟雾(二手烟);据估计,全世界有40%的儿童接触二手烟。