nephroblastoma 英 /,nefrəublæ'stəumə/ 美 /,nefrəublæ'stəumə/
释 义 n. [肿瘤] 肾胚细胞瘤
例 句 For these years, residua of metanephric blastema and delay of differentiation in the development of kidney have been considered the cause of nephroblastoma.近年来的研究发现，肾发育过程中的胚基残留，分化障碍可能是肾母细胞瘤发病的原因之一。
作者： Rautenberg Christina
期刊：Blood Cancer J
Few reports suggested a prognostic impact of Wilms'Tumor-1 (WT1)-mRNA overexpression in MDS, but translation into clinical routine was hampered by limited patients numbers, differing sample sources, non-standardized methods/cut-offs. To evaluate whether WT1-mRNA expression yields additional prognostic information, we measured peripheral blood (PB) WT1-mRNA expression in 94 MDS using a standardized assay offering a validated cut-off to discriminate between normal and WT1-mRNA overexpression. Overall, 54 patients (57%) showed WT1-mRNA overexpression, while 40 patients (43%) had normal WT1-mRNA expression. This enabled discrimination between MDS and both healthy controls and non-MDS cytopenias. Furthermore, WT1-mRNA expression correlated with WHO 2016 subcategories and IPSS-R as indicated by mean WT1-mRNA expression and frequency of WT1-mRNA overexpressing patients within respective subgroups.