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Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours.
直肠指检后尿液中的肌氨酸不能作为前列腺癌检测和鉴别侵袭性肿瘤的标志物。

摘要

BACKGROUND:Sarcosine in urine was recently suggested to be a promising tool in prostate cancer (PCa) diagnostics.
OBJECTIVE:To reevaluate sarcosine as a potential biomarker for early PCa detection and for prediction of tumour aggressiveness.
DESIGN, SETTING, AND PARTICIPANTS:Sarcosine was measured in urine samples from 106 PCa patients and 33 patients with no evidence of malignancy (NEM), confirmed by 8-12 core prostate biopsies, after standardised digital rectal examination, as well as from 12 healthy men and women. The results were related to the clinicopathologic data on prostate volume, tumour stage, Gleason score, and prostate specific antigen (PSA).
MEASUREMENTS:Sarcosine in urine was determined by gas chromatography-mass spectrometry using a commercial amino acid assay and was normalised to urine creatinine. Nonparametric statistical tests and receiver operating characteristics (ROC) analyses were performed to assess the diagnostic performance.
RESULTS AND LIMITATIONS:The median sarcosine-creatinine ratio in urine was 13% lower in PCa than in NEM patients. Sarcosine values were not associated with tumour stage (pT2 vs pT3) or grade (Gleason score  or = 7). ROC analyses proved that the discrimination between PCa and NEM patients was not improved by sarcosine in comparison with total PSA, but it was significantly worse than the percent free PSA. The higher proportion of PCa than NEM patients can be considered a limitation of this study.
CONCLUSIONS:Sarcosine in urine after rectal digital examination cannot be considered as a suitable marker to differentiate between patients with and without PCa.

译文

背景: 尿液中的肌氨酸最近被认为是前列腺癌 (PCa) 诊断的一个有前途的工具。
目的: 重新评估肌氨酸作为早期 PCa 检测和预测肿瘤侵袭性的潜在生物标志物。
设计、背景和参与者: 肌氨酸在 106 名 PCa 患者和 33 名无恶性证据的患者的尿液样本中进行了测量,经 8-12 次前列腺活检证实, 经过标准化的直肠指检,以及来自 12 名健康男性和女性的检查。结果与前列腺体积、肿瘤分期、 Gleason 评分和前列腺特异性抗原 (PSA) 的临床病理资料相关。
测量: 尿中的肌氨酸通过使用商业氨基酸测定的气相色谱-质谱法测定,并标准化为尿肌酐。进行非参数统计检验和受试者工作特征 (ROC) 分析以评估诊断性能。
结果和局限性: PCa 患者尿液中肌氨酸-肌酐比值中位数比 NEM 患者低 13%。肌氨酸值与肿瘤分期 (pT2 vs pT3) 或分级 (Gleason 评分 or = 7) 无关。ROC 分析证明,与总 PSA 相比,肌氨酸并没有提高 PCa 和 NEM 患者之间的区分度,但显著低于游离 PSA 的百分比。PCa 患者比 NEM 患者更高的比例可以被认为是本研究的一个限制。
结论: 直肠指检后尿液中的肌氨酸不能被认为是区分有和没有 PCa 患者的合适标记。

Digital rectal examination

儿科 胃肠道 治疗方法
概述  :  

直肠指检是一种操作简单的筛查手段,大致可以确定距肛缘7-10 cm的肛门、直肠有无病变和病变的性质,如:诊断直肠肿瘤、评估肛门功能并判断有无失禁、了解痔的范围、辅助诊断阑尾炎、检查盆腔脏器,如前列腺(男性)、子宫(女性)等。适应征①排便习惯改变:如无明显诱因出现大便次数增多、便秘与腹泻交替、排便不尽感、大便变细或变形等;②大便性状改变:大便变稀、带血和黏液;③肛门疼痛:常见于肛裂、肛周脓肿,肛周脓肿应早期发现并及早切开排脓,一般的抗感染药物治疗是无效的;④肛门流脓、流液:可能是肛

digital 英 /ˈdɪdʒɪtl/  美 /ˈdɪdʒɪtl/

释    义   n. 数字;键     

adj. 数字的;手指的

例    句   The preoperative digital anal examination, rectal intraluminal ultrasound, pelvic CT and MRI candirect the selection of operative indication. 术前肛门指诊、直肠腔内超声、盆腔CT及MRI可指导手术适应证的选择。

 

rectal 英 /ˈrektəl/  美 /ˈrektəl/

释    义   adj. 直肠的

例    句   The effect of screening with prostate-specific–antigen (PSA) testing and digital rectalexamination on the rate of death from prostate cancer is unknown. 前列腺特异抗原(PSA)筛查和直肠指检对于前列腺癌死亡率的影响尚无结论。

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