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首页 > 医学词汇大全 > Fat embolism syndrome
Fat embolism syndrome

儿科

关键词儿科 疾病 罕见疾病

词汇介绍

拓展阅读

解析

fat 英 /fæt/  美 /fæt/

释    义   n. 脂肪,肥肉      

adj. 肥的,胖的;油腻的;丰满的      

vt. 养肥;在…中加入脂肪      

vi. 长肥

例    句   All cases, no cases of intraoperative fracture, fat embolism syndrome and other postoperative complications.所有病例中无术中骨折病例、术后脂肪栓塞综合症及其它并发症的发生。

 

embolism 英 /ˈembəlɪzəm/  美 /ˈembəlɪzəm/

释    义   n. 栓塞;闰日

例    句   Fat embolism syndrome is a serious complication after trauma or bone fracture, which may occurduring orthopedic operation.  脂肪栓塞综合征是创伤或骨折后的严重并发症,矫形外科及骨科手术中也可发生。

概述

脂肪栓塞综合征(FES)是一种罕见疾病,严重时可导致呼吸衰竭、神经认知障碍和死亡。其难以诊断,但需要及时识别,以便尽早开始支持性治疗。流行病学和病因1、骨折或创伤 FES在骨科创伤患者中的发生率从<1%到>30%不等,这种巨大差异可能是反映了研究人群的异质性和缺乏标准化的诊断思路。FES大多是因长骨和骨盆骨折而发生,少数病例是在肋骨等其他有髓骨骨折后发生。多发性骨折患者的FES发生率也高于孤立性骨折患者。FES在闭合性骨折中的发生率高于开放性骨折。男性的FES发生率高于

Bone Health and Osteoporosis Management of the Patient With Duchenne Muscular Dystrophy复制标题

Duchenne型肌营养不良患者的骨健康和骨质疏松管理

发表时间:2018-10-01

影响因子:5.4

作者: Ward Leanne M

期刊:Pediatrics

Duchenne muscular dystrophy is associated with an increased risk of bone fragility due to the adverse effects of prolonged glucocorticoid therapy and progressive muscle weakness on bone strength. Osteoporosis manifests clinically as low-trauma long-bone and vertebral fractures (VFs), with VFs frequent, particularly in those treated with glucocorticoid therapy. It is increasingly recognized that bone pain, medical complications of osteoporosis (such as fat embolism syndrome), and the potential for permanent, fracture-induced loss of ambulation can be mitigated with timely bone health surveillance and management. This includes periodic spine radiographs for VF detection because VFs can be asymptomatic in their early phases and thereby go undetected in the absence of monitoring. With this article, we provide a comprehensive review of the following 4 phases of bone health management: (1) bone health monitoring, which is used to identify early signs of compromised bone health; (2) osteoporosis stabilization, which is aimed to mitigate back pain and interrupt the fracture-refracture cycle through bone-targeted therapy; (3) bone health maintenance, which has the goal to preserve the clinical gains realized during the stabilization phase through ongoing bone-targeted therapy; and (4) osteoporosis therapy discontinuation, which places those who are eligible for discontinuation of osteoporosis treatment back on a health monitoring program.

译文

Duchenne型肌营养不良与骨脆性风险增加有关,因为长期糖皮质激素治疗和进行性肌肉无力对骨强度的不利影响。骨质疏松症临床表现为低创伤长骨和椎体骨折(VFs),VFs多见,尤其是糖皮质激素治疗者。人们越来越认识到,通过及时的骨健康监测和管理,可以减轻骨痛、骨质疏松症的医疗并发症(如脂肪栓塞综合征)和永久性骨折引起的行走障碍的可能性。这包括用于心室颤动检测的周期性脊柱x光片,因为心室颤动在早期可能无症状,因此在没有监测的情况下无法检测到。本文对骨健康管理的4个阶段进行了综述:(1)骨健康监测,用于识别骨健康受损的早期征兆;(2)骨质疏松稳定,通过骨靶向治疗减轻背痛,中断骨折再骨折周期;(3)骨健康维护,其目标是通过持续的骨靶向治疗保持稳定阶段实现的临床收益;和(4)骨质疏松症治疗中止,将那些有资格中止骨质疏松症治疗的人重新纳入健康监测计划。