摘要

The effects of insulin-like growth factor-I on bone tissue and its role in bone development have been extensively investigated, but there is little information on its role in the pathogenesis of aneurysmal bone cyst. Therefore, using the techniques of immunohistochemistry and in situ hybridization, the authors studied the expression of insulin-like growth factor-I in 19 specimens of aneurysmal bone cyst. Insulin-like growth factor-I or specific mRNA sequences encoding for insulin-like growth factor-I were detectable in all specimens tested and were mainly localized in multinucleate giant cells. In contrast, only insignificant levels of insulin-like growth factor-I expression were detectable in normal human bone tissue. Taken together with the previously reported role of insulin-like growth factor-I in the pathogenesis of giant cell tumor, the findings of this study suggest that insulin-like growth factor-I may play a role in the pathogenesis of aneurysmal bone cyst.

译文

胰岛素样生长因子-I 对骨组织的作用及其在骨发育中的作用已经被广泛研究,但是关于其在动脉瘤样骨囊肿发病机制中的作用的信息很少。因此,利用免疫组织化学和原位杂交技术,作者研究了胰岛素样生长因子-I 在 19 例动脉瘤样骨囊肿标本中的表达。胰岛素样生长因子-I 或编码胰岛素样生长因子-I 的特定 mRNA 序列在所有测试的标本中都可检测到,主要定位于多核巨细胞。相比之下,在正常人体骨组织中只能检测到无关紧要的胰岛素样生长因子-I 表达水平。结合先前报道的胰岛素样生长因子-I 在巨细胞肿瘤发病机制中的作用, 这项研究的结果表明胰岛素样生长因子-I 可能在动脉瘤样骨囊肿的发病机制中发挥作用。

Bone cyst

儿科 囊肿 临床研究术语
概述  :  

骨囊肿也称孤立性骨囊肿,是一种常见的良性肿瘤样病损。骨囊肿的确切病因不明,学说很多,Mirra推测可能是在胚胎时期少许具有分泌功能的滑膜细胞陷入骨内,结果引起滑液聚集而形成骨囊肿。骨囊肿在其发展过程中很少出现症状,大部分病人是由于外伤造成病理性骨折后产生局部肿痛、肿胀、压痛、不能活动等骨折表现而发现。少数病例表现为局部包块或骨增粗,关节活动多正常,肌肉可轻度萎缩。发生在下肢的患者,偶有跛行。发病机制1、骨内静脉梗阻这一学说的具体说法为:骨在生长和发育过程中发生局部发育异常使局部静脉回流受阻

bone

释    义   n. 骨;骨头

vt. 剔去…的骨

vi. 苦学;专心致志

例    句   Many passengers suffered broken bones. 许多乘客骨折了。

 

cyst 英 /sɪst/  美 /sɪst/

释    义   n. [肿瘤] 囊肿;[生物] 包囊;膀胱

例    句   The pure cyst most sees in the galactoma. 单纯囊肿在乳腺囊肿中最为多见。

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