微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Astrocytic tumors
Astrocytic tumors

儿科

关键词儿科 临床研究术语 肿瘤

词汇介绍

拓展阅读

解析

astrocytic /,æstrə'sɪtɪk/

释    义   adj. 星形细胞的

例    句   The peritumoral edema on MRI in supratentorial astrocytic gliomas can reflect thepositive expression rate of P53 protein. 星形细胞瘤的瘤周水肿MRI表现反映了肿瘤组织P53蛋白的表达程度。

 

tumor 英 /'tju:mə(r)/  美 /'tjʊmɚ/

释    义   n. 肿瘤;肿块;赘生物

例    句   So anti angiogenesis will be an efficient method in the inhibition of the growth and metastasis oftumor.  所以抗血管生成将是一种很有希望的对抑制肿瘤生长和转移的有效方法。

概述

毛细胞型星形细胞瘤是最常见的儿童小脑肿瘤,大多数患者在20岁内发病,临床表现因肿瘤部位而异,最常见的症状为头痛、恶心、呕吐等,视神经处肿瘤以视物模糊,视物双影等症状为主,小脑患者可出现椎体外系受损症状,脊髓内肿瘤可引起偏瘫或半瘫,肿瘤累及大脑皮质者可引发癫痈发作。病理学表现及分子生物学的改变肿瘤大体标本为质软的灰色肿块,边界清楚,有或无囊肿,典型镜下表现为组织呈双相结构,由致密区毛发样梭形细胞伴Rosenthal纤维和疏松区多极细胞伴微囊及嗜酸性颗粒小体组成,具有肾小球样特征的大量血管。星

BRAF V600E mutant oligodendroglioma-like tumors with chromosomal instability in adolescents and young adults复制标题

BRAF V600E突变少突神经胶质瘤样肿瘤伴染色体不稳定性的青少年和年轻人

发表时间:2019-10-19

影响因子:6.2

作者: Fukuoka Kohei

期刊:Brain Pathol

We performed genome-wide methylation analysis on 136 pediatric low grade gliomas, identifying a unique cluster consisting of 3 tumors with oligodendroglioma-like histology, BRAF p.V600E mutations and recurrent whole chromosome gains of 7 and loss of 10. Morphologically, all showed similar features, including a diffusely infiltrative glioma composed of round nuclei with perinuclear halos, a chicken-wire pattern of branching capillaries and microcalcification. None showed astrocytic features or characteristics suggestive of high-grade tumors including necrosis or mitotic figures. All tumors harbored multiple chromosomal copy number abnormalities (>10 chromosomes altered), but none showed 1p/19q co-deletion or IDH1 p.R132H mutation. Hierarchical clustering and t-stochastic neighbor embedding analyses from DNA methylation data cluster them more closely to previously described pediatric-type low grade gliomas and separate from adult gliomas. These tumors exhibit distinct clinical features; they are temporal lobe lesions occurring in adolescents and young adults with a prolonged history of seizures and all are alive with no recurrence (follow-up 3.2 to 13.2 years).

译文

我们对136例儿童低级别胶质瘤进行了全基因组甲基化分析,确定了一个独特的簇,由3个具有少突胶质瘤样组织学、BRAF p.V600E突变和复发性全染色体增益7和丢失10的肿瘤组成形态学上,均表现出相似的特征,包括弥漫性浸润性胶质瘤,由核周晕的圆形核组成,毛细血管分支呈鸡丝状,微钙化无一例显示星形细胞特征或提示高级别肿瘤的特征,包括坏死或有丝分裂。所有肿瘤均存在多染色体拷贝数异常(>10条染色体改变),但无1p/19q共缺失或idh1p.r132h突变。dna甲基化数据的分层聚类和t-随机邻域嵌入分析更接近于先前描述的儿童型低级别胶质瘤,并与成人胶质瘤分离。这些肿瘤表现出明显的临床特征;它们是青少年和年轻人的颞叶病变,有长期的癫痫发作史,所有肿瘤均存活,无复发(随访3.2至13.2年)。