摘要

PURPOSE:Carbonic anhydrase IX (CA IX) is a hypoxia-inducible enzyme, which is associated with neoplastic growth. Ectopic CA IX expression has been observed in several tumors, whose normal counterparts do not express this enzyme. Normal human brain tissue shows only slight or no expression of CA IX.
EXPERIMENTAL DESIGN:We describe CA IX expression in human diffusely infiltrating astrocytomas. The association of CA IX is evaluated with clinicopathologic and molecular factors including cell proliferation and apoptosis as well as the expression of p53 and epidermal growth factor receptor.
RESULTS:CA IX immunopositivity was observed in 284 cases of 362 (78%) tumors. The positive areas were often located in close proximity to necrotic regions (P < 0.001). The CA IX immunoreactivity showed strong association with tumor malignancy grades (P < 0.0001). CA IX showed no association with p53 expression nor did it correlate with epidermal growth factor receptor-amplification, apoptosis, or cell proliferation. CA IX intensity had significant prognostic value in univariate (P=0.0011, log-rank test) and multivariate survival analysis (P = 0.038, Cox analysis).
CONCLUSIONS:CA IX expression is common in diffusely infiltrating high-grade astrocytomas. Our results suggest that CA IX is a useful biomarker for predicting poor prognosis of astrocytic tumors. It may also be a promising target molecule for the improvement of therapeutic interventions in astrocytomas.

译文

目的: 碳酸氢酶 IX (CA IX) 是一种缺氧诱导酶,与肿瘤生长相关。在一些肿瘤中观察到 CA IX 的异位表达,这些肿瘤的正常对应方不表达这种酶。正常人脑组织仅显示 CA IX 的轻微或无表达。
实验设计: 我们描述了 CA IX 在人弥漫浸润星形细胞瘤中的表达。CA IX 与临床病理和分子因素的关系被评估,包括细胞增殖和凋亡以及 p53 和表皮生长因子受体的表达。
结果: 在 284 例 362 (78%) 肿瘤中观察到 CA IX 免疫阳性。阳性区域通常位于坏死区域附近 (P & lt; 0.001)。CA IX 免疫反应性显示与肿瘤恶性程度密切相关 (P & lt; 0.0001)。CA IX 与 p53 表达无关,也与表皮生长因子受体扩增、细胞凋亡或细胞增殖无关。CA IX 强度在单因素 (P = 0.0011,log-rank 检验) 和多因素生存分析 (P = 0.038,Cox 分析) 中具有显著的预后价值。
结论: CA IX 在弥漫浸润的高级别星形细胞瘤中常见。我们的结果表明 CA IX 是预测星形细胞肿瘤不良预后的有用生物标志物。它也可能是星形细胞瘤治疗干预改善的一个有前途的靶分子。

Astrocytic tumors

儿科 肿瘤 临床研究术语
概述  :  

毛细胞型星形细胞瘤是最常见的儿童小脑肿瘤,大多数患者在20岁内发病,临床表现因肿瘤部位而异,最常见的症状为头痛、恶心、呕吐等,视神经处肿瘤以视物模糊,视物双影等症状为主,小脑患者可出现椎体外系受损症状,脊髓内肿瘤可引起偏瘫或半瘫,肿瘤累及大脑皮质者可引发癫痈发作。病理学表现及分子生物学的改变肿瘤大体标本为质软的灰色肿块,边界清楚,有或无囊肿,典型镜下表现为组织呈双相结构,由致密区毛发样梭形细胞伴Rosenthal纤维和疏松区多极细胞伴微囊及嗜酸性颗粒小体组成,具有肾小球样特征的大量血管。星

astrocytic /,æstrə'sɪtɪk/

释    义   adj. 星形细胞的

例    句   The peritumoral edema on MRI in supratentorial astrocytic gliomas can reflect thepositive expression rate of P53 protein. 星形细胞瘤的瘤周水肿MRI表现反映了肿瘤组织P53蛋白的表达程度。

 

tumor 英 /'tju:mə(r)/  美 /'tjʊmɚ/

释    义   n. 肿瘤;肿块;赘生物

例    句   So anti angiogenesis will be an efficient method in the inhibition of the growth and metastasis oftumor.  所以抗血管生成将是一种很有希望的对抑制肿瘤生长和转移的有效方法。

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