儿科
词汇介绍
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解析
ankylose 英 /'æŋkɪləʊz/ 美 /'æŋkə,los/
释 义 v. （使）（关节等处的骨头）长合；（使）僵硬
例 句 To study the relationship between disease activity and osteoporosis in patients withjuvenile ankylosing spondylitis and to clarify the effect of prednisone therapy on osteoporosis. 目的：探讨幼年型强直性脊柱炎病人的疾病活动性与骨质疏松的关系以及服用强的松对骨质疏松的影响。
spondylitis 英 /,spɒndɪ'laɪtɪs/ 美 /,spɑndɪ'laɪtɪs/
释 义 n. [外科] 脊椎炎
例 句 This radiograph of the pelvis of a patient with ankylosing spondylitis shows bilateral sacroiliitis with sclerosis and narrowing of the sacroiliac joints. 这是一个强直性脊柱炎患者的骨盆正位片，显示双侧骶髂关节炎，伴随硬化与关节间隙狭窄。
概述
The IL-23-IL-17 pathway as a therapeutic target in axial spondyloarthritis.
复制标题
IL-23-IL-17通路作为中轴型脊柱关节炎的治疗靶点。
发表时间：2019-09-24
影响因子：18.5
作者： Sieper Joachim
期刊：Nat Rev Rheumatol
The cytokines IL-23 and IL-17 have an important role in the pathogenesis of, and as a therapeutic target in, both animal models of chronic inflammation and some human chronic inflammatory diseases. The traditional view is that a main source of IL-17 is T cells and that IL-17 production is under the control of IL-23. IL-17 inhibition has shown good efficacy in clinical trials for ankylosing spondylitis (AS), a subtype of axial spondyloarthritis (axSpA) characterized by radiographic evidence of sacroiliitis. On the basis of data from animal models, genetic studies and the investigation of tissue and blood samples from patients with AS, IL-23 had also been predicted to be important in the pathogenesis of this disease and was therefore considered a potential therapeutic target for axSpA. However, two placebo-controlled, double-blind clinical trials in axSpA of monoclonal antibodies directed against either the p40 protein or the p19 protein of the IL-23 molecule had clear negative results.
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