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Ankylosing spondylitis

儿科

关键词儿科 疾病 慢性进行性疾病

词汇介绍

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解析

ankylose 英 /'æŋkɪləʊz/  美 /'æŋkə,los/

释    义   v. (使)(关节等处的骨头)长合;(使)僵硬

例    句   To study the relationship between disease activity and osteoporosis in patients withjuvenile ankylosing spondylitis and to clarify the effect of prednisone therapy on osteoporosis. 目的:探讨幼年型强直性脊柱炎病人的疾病活动性与骨质疏松的关系以及服用强的松对骨质疏松的影响。

 

spondylitis 英 /,spɒndɪ'laɪtɪs/ 美 /,spɑndɪ'laɪtɪs/

释    义   n. [外科] 脊椎炎

例    句   This radiograph of the pelvis of a patient with ankylosing spondylitis shows bilateral sacroiliitis with sclerosis and narrowing of the sacroiliac joints. 这是一个强直性脊柱炎患者的骨盆正位片,显示双侧骶髂关节炎,伴随硬化与关节间隙狭窄。

概述

强直性脊柱炎(AS)是一种慢性进行性疾病,主要侵犯骶髂关节、脊柱骨突、脊柱旁软组织及外周关节,并可伴发关节外表现。严重者可发生脊柱畸形和关节强直。AS是脊柱关节病的原型或称原发性AS;其他脊柱关节病并发的骶髂关节炎为继发性AS。通常所指均为前者。发病率AS的患病率在各国报道不一,日本本土人为0.05%-0.2%,我国患病率初步调查为0.26%。以往认为本病男性多见,男女之比为10.6:1,现报告男女之比为5:1,只不过女性发病较缓慢及病情较轻。发病年龄通常在13~31岁,30岁以后及8岁以前

The IL-23-IL-17 pathway as a therapeutic target in axial spondyloarthritis.复制标题

IL-23-IL-17通路作为中轴型脊柱关节炎的治疗靶点。

发表时间:2019-09-24

影响因子:18.5

作者: Sieper Joachim

期刊:Nat Rev Rheumatol

The cytokines IL-23 and IL-17 have an important role in the pathogenesis of, and as a therapeutic target in, both animal models of chronic inflammation and some human chronic inflammatory diseases. The traditional view is that a main source of IL-17 is T cells and that IL-17 production is under the control of IL-23. IL-17 inhibition has shown good efficacy in clinical trials for ankylosing spondylitis (AS), a subtype of axial spondyloarthritis (axSpA) characterized by radiographic evidence of sacroiliitis. On the basis of data from animal models, genetic studies and the investigation of tissue and blood samples from patients with AS, IL-23 had also been predicted to be important in the pathogenesis of this disease and was therefore considered a potential therapeutic target for axSpA. However, two placebo-controlled, double-blind clinical trials in axSpA of monoclonal antibodies directed against either the p40 protein or the p19 protein of the IL-23 molecule had clear negative results.

译文

细胞因子il-23和il-17在慢性炎症动物模型和某些慢性炎症疾病的发病机制中起着重要作用,并作为治疗靶点。传统观点认为il-17的主要来源是t细胞,il-17的产生受il-23的控制。IL-17抑制在强直性脊柱炎(AS)的临床试验中显示出良好的疗效,强直性脊柱炎(AS)是一种以骶髂关节炎的影像学表现为特征的轴型脊椎关节炎(AXSPA)的亚型。根据动物模型、遗传研究和as患者组织和血液样本的研究,il-23在as发病中也具有重要作用,因此被认为是axspa的潜在治疗靶点。然而,在axspa的两个安慰剂对照、双盲临床试验中,针对il-23分子的p40蛋白或p19蛋白的单克隆抗体都有明显的阴性结果。