摘要

The disease profile in the Indian population provides a unique opportunity for studying the host microbiome interaction in both infectious (amebiasis) and autoimmune diseases like inflammatory bowel disease (IBD) from a similar environment and genetic background. Analysis of fecal samples from untreated amebic liver abscess (ALA) patients, Entamoeba histolytica (Eh)-negative and -positive asymptomatic individuals, and pus samples from naive ALA patients revealed a significant reduction in Lactobacillus in asymptomatic individuals (Eh +ve) and ALA patients. Two anaerobic genera, namely Bacteroides and Peptostreptococcus, were detected in naive ALA pus samples. Analysis of fecal samples from amoebic colitis patients showed a significant decline in population of Bacteroides, Clostridium coccoides and leptum subgroup, Lactobacillus, Campylobacter, and Eubacterium, whereas a significant increase in Bifidobacterium was observed. Mucosa-associated bacterial flora analysis from IBD patients and healthy controls revealed a significant difference in concentration of bacteria among predominating and subdominating genera between ulcerative colitis (UC), Crohn's disease (CD) patients, and controls.

译文

印度人群的疾病特征为从相似的环境和遗传背景研究传染性疾病(阿米巴病)和自身免疫性疾病(如炎症性肠病(ibd))中宿主微生物的相互作用提供了一个独特的机会。对未经治疗的阿米巴肝脓肿(ala)、溶组织内阿米巴(eh)阴性和阳性无症状个体的粪便样本以及未经治疗的ala患者的脓液样本的分析显示,无症状个体(eh+ve)和ala患者的乳酸杆菌显著减少。在未经培养的ala脓液中检测到两个厌氧菌属,即拟杆菌属和消化链球菌属。对阿米巴结肠炎患者粪便样本的分析显示,类杆菌、类球菌梭菌和瘦素亚群、乳酸杆菌、弯曲杆菌和真杆菌的数量显著下降,而双歧杆菌的数量显著增加。对ibd患者和健康对照者的粘膜相关菌群分析显示,溃疡性结肠炎(uc)、克罗恩病(cd)患者和对照者的优势属和亚优势属之间的细菌浓度存在显著差异。

Amebic liver abscess

儿科 阿米巴肠病 临床研究术语
概述  :  

阿米巴肠病常并发阿米巴肝脓肿,国内临床资料约占1.8~10%,亦有高达46%者,国外尸检材料为10~59%。近年由于有效的药物与必要时加用准确超声导引下抽脓,病情已不难控制。起病较缓慢,病情较长,可有高热,不规则发热,盗汗。临床表现症状本病的发展过程一般比较缓慢,急性阿米巴肝炎期较短暂。继之为较长时期的慢性期。主要为发热,肝区疼痛及肝肿大。体温多持续在38~39℃,常为弛张热或间歇热;在肝脓肿后期,体温可正常或低热。如继发细菌感染,体温可达40℃以上,伴有畏寒、多汗、食欲不振、腹胀,恶心、

amebic 英 /ə'mi:bik/  美 /ə'mi:bik/

释    义   adj. 阿米巴的;变形虫的

例    句   Amebic dysentery is B type infectious disease legally. 阿米巴痢疾为法定乙类传染病。

 

liver 英 /ˈlɪvə(r)/  美 /ˈlɪvər/

释    义   n. 肝脏;生活者,居民

例    句   They also found particles in the liver cells of patients with hepatitis. 他们在肝炎病人的肝细胞也发现了这种微粒。


abscess 英 /ˈæbses/  美 /ˈæbses/

释    义   n. 脓肿;脓疮     

vi. 形成脓肿

例    句   In children, it is important to consider the maximum doses of local anesthetics when performing alaceration repair or painful procedure like abscess drainage. 对于儿童来说,在做撕裂伤的修复或象脓肿引流这样痛苦的操作时,一定要考虑到局麻药的最大剂量。

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