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首页 > 医学词汇大全 > Disseminated intravascular coagulation
Disseminated intravascular coagulation

儿科

关键词儿科 临床研究术语 血液

词汇介绍

拓展阅读

解析

disseminated  英 /dɪ'semɪneɪtɪd/ 美 /dɪ'sɛmə,net/

释    义   v. 散布(disseminate的过去分词);撒播  

adj. 浸染的;散播性的

例    句   Severe gram negative bacteria infection is a common cause of disseminated intravascularcoagulation (DIC) and multiple organ failure (MOF). 革兰阴性杆菌所致重症感染常引起弥散性血管内凝血和多器官功能衰竭。

 

intravascular 英 /,ɪntrə'væskjʊlə/ 美 /,ɪntrə'væskjəlɚ/

释    义   adj. 血管内的

例    句   The pharmacodynamic process accorded with the one chamber open model of intravascular administration. 其药效动力学过程符合血管外给药的一室开放模型。

 

coagulation 英 /kəʊ,æɡjʊ'leɪʃən/ 美 /koʊˌæɡjuˈleɪʃn/

释    义   n. 凝固,凝结;凝结物

例    句   The ultrafiltration rate of pure water with the coagulation bath temperature increased.  随着凝固浴温度的升高,所成的膜的透水速率上升。

概述

弥散性血管内凝血(DIC)是在许多疾病基础上,致病因素损伤微血管体系,导致凝血活化,全身微血管血栓形成、凝血因子大量消耗并继发纤溶亢进,引起以出血及微循环衰竭为特征的临床综合征。在DIC发生发展的过程中涉及到凝血、抗凝、纤溶等多个系统,临床表现也多样化,容易与其他引起出凝血异常疾病相混淆,因此DIC的诊断仍然是一项需要丰富专业经验和具有挑战性的工作。发病机制弥散性血管内凝血始于凝血系统被激活。在某些致病因子作用下,凝血因子和血小板被激活,凝血酶增多,微循环中发生广泛的凝血过程,即DIC的基

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways复制标题

肽聚糖通过激活两种凝血途径诱导狒狒弥散性血管内凝血

发表时间:2018-08-23

影响因子:16.6

作者: Popescu Narcis I

期刊:Blood

Anthrax infections exhibit progressive coagulopathies that may contribute to the sepsis pathophysiology observed in fulminant disease. The hemostatic imbalance is recapitulated in primate models of late-stage disease but is uncommon in toxemic models, suggesting contribution of other bacterial pathogen-associated molecular patterns (PAMPs). Peptidoglycan (PGN) is a bacterial PAMP that engages cellular components at the cross talk between innate immunity and hemostasis. We hypothesized that PGN is critical for anthrax-induced coagulopathies and investigated the activation of blood coagulation in response to a sterile PGN infusion in primates. The PGN challenge, like the vegetative bacteria, induced a sepsis-like pathophysiology characterized by systemic inflammation, disseminated intravascular coagulation (DIC), organ dysfunction, and impaired survival. Importantly, the hemostatic impairment occurred early and in parallel with the inflammatory response, suggesting direct engagement of coagulation pathways.

译文

炭疽感染表现为进行性凝血病变,可能与暴发性疾病中观察到的败血症病理生理学有关。在晚期疾病的灵长类动物模型中,止血不平衡被重新描述,但在毒血症模型中并不常见,这表明其他细菌-病原体相关分子模式(pamps)的贡献。肽聚糖(pgn)是一种细菌pamp,在天然免疫和止血之间的相互作用中与细胞成分结合。我们假设pgn对炭疽引起的凝血病至关重要,并研究了灵长类动物输注无菌pgn后凝血的激活。pgn激发与植物性细菌一样,诱发了一种脓毒症样的病理生理学,其特征是全身炎症、弥散性血管内凝血(dic)、器官功能障碍和生存受损。重要的是,止血损伤早期发生,并与炎症反应同时发生,提示凝血途径直接参与。