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首页 > 医学词汇大全 > Atrial septal defect
Atrial septal defect

儿科

关键词儿科 临床研究术语 先天性心脏畸形

词汇介绍

拓展阅读

解析

atrial    英 /'eɪtrɪəl/  美 /'eɪtriəl/

释    义   adj. 心房的;门廊

例    句   Atrial fibrillation is one of the most common arrhythmias. 心房颤动是最常见的心律失常之一。

 

septal    英 /'sept(ə)l/  美 /'sɛptl/

释    义   adj. 中隔的;氏族的;隔膜的

例    句   Ventricular septal defect(VSD) is one of the most common congenital heart malformations. 室间隔缺损是最常见的先天性心脏病之一。


defect    英 /'diːfekt; dɪ'fekt/  美 /‘dɪfɛkt/

释    义   n. 缺点,缺陷;不足之处     

vi. 变节;叛变

例    句   The study concluded that Fc calculated by correcting the effect of left ventricular outflow on flowconvergence region can more accurately evaluate the shunt severity of ventricular septal defect.该研究表明通过校正左室流出道血流对会聚区的影响计算出的分流率能更准确地评估室间隔缺损的分流程度。

概述

房间隔缺损(ASD)是临床常见的左向右分流性先心病,是左右心房在胚胎期分隔时残存的孔洞。占整个先心病的5%-10%,男女性别比例为1:2。根据胚胎发生,房间隔缺损可分为以下四个类型,出生后左房压高于右房,如存在房缺则出现左向右分流,分流量与缺损大小、两侧心房压力差及心室的顺应性有关,并出现相应的临床症状。血流动力学出生后左房压高于右房,如存在房缺则出现左向右分流,分流量与缺损大小、两侧心房压力差及心室的顺应性有关。生后初期左、右心室壁厚度相似,顺应性也相近故分流量不多。随年龄增长,肺血管阻力

Interventional Therapy Versus Medical Therapy for Secundum Atrial Septal Defect: A Systematic Review (Part 2) for the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease复制标题

介入治疗与药物治疗继发孔型房间隔缺损: 2018 AHA/ACC成人先天性心脏病治疗指南的系统评价 (第二部分)

发表时间:2019-04-15

影响因子:18.6

作者: Matthew Oster

期刊:J Am Coll Cardiol

Secundum atrial septal defect (ASD) is the most common adult congenital heart defect and can present with wide variation in clinical findings. With the intention of preventing morbidity and mortality associated with late presentation of ASD, consensus guidelines have recommended surgical or percutaneous ASD closure in adults with right heart enlargement, with or without symptoms. The aim of the present analysis was to determine if the protective effect of secundum ASD closure in adults could be qualified by pooling data from published studies. A systematic review and meta-analysis were performed by using EMBASE, MEDLINE (through PubMed), and the Cochrane Library databases to assess the effect of secundum ASD percutaneous or surgical closure in unoperated adults ≥18 years of age. Data were pooled across studies with the DerSimonian-Laird random-effects model or a Bayesian meta-analysis model.

译文

继发房间隔缺损(asd)是成人最常见的先天性心脏病,临床表现多样。为了预防晚期ASD的发病率和死亡率,一致的指南建议对有或无症状的右心增大的成人行外科或经皮ASD封堵术。本分析的目的是通过收集已发表研究的数据来确定成人继发性房间隔缺损闭合术的保护效果是否合格。采用embase、medline(通过pubmed)和cochrane文库数据库,对年龄≥18岁的未手术成人进行了系统回顾和荟萃分析,以评估经皮或手术治疗继发性asd的效果。数据通过德西蒙莱尔德随机效应模型或贝叶斯荟萃分析模型进行汇总。