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首页 > 医学词汇大全 > Chronic lung disease
Chronic lung disease

儿科

关键词儿科 疾病 肺疾病

词汇介绍

拓展阅读

解析

chronic 英 [ˈkrɒnɪk]  美 [ˈkrɑːnɪk]

释    义   adj. 慢性的;长期的;习惯性的

例    句   Most of them were chronically ill. 他们中大部分人都有慢性病。

 

lung

释    义   n. 肺;呼吸器

例    句   A smoker who died of lung cancer.一位死于肺癌的吸烟者

 

disease

释    义   n. 病,[医] 疾病;弊病

vt. 传染;使…有病

例    句   The rapid spread of disease in the area.疾病在这一地区的迅速传播。

概述

新生儿慢性肺疾病(CLD)主要发生于胎龄和出生体重相对较大(平均胎龄34周、出生体重2 200 g)的早产儿。感染、高浓度氧、高气道压的机械通气导致的肺损伤是其主要病因。半个世纪以来,由于围产医学的发展以及产前糖皮质激素和生后外源性肺表面活性物质(PS)的应用,CLD的表现形式已发生了很大变化,更为常见的是一种轻型CLD(又称为“新”CLD),患儿通常是出生体重<1 000 g,胎龄<26周的极不成熟早产儿,宫内感染、生后各种不利因素导致的肺泡和肺微血管发育受阻或停滞是其主要病因。病因BP

Beyond the Lungs: Systemic Manifestations of Pulmonary Arterial Hypertension复制标题

肺之外: 肺动脉高压的全身表现

发表时间:2019-09-12

影响因子:16.5

作者: Nickel Nils P

期刊:Am J Respir Crit Care Med

Pulmonary arterial hypertension (PAH) is a disease characterized by progressive loss and remodeling of the pulmonary arteries resulting in right heart failure and death. Until recently, PAH was seen as a disease restricted to the pulmonary circulation. However, there is growing evidence that PAH patients also exhibit systemic vascular dysfunction, as evidenced by impaired brachial artery flow-mediated dilation, abnormal cerebral blood flow, skeletal myopathy, and intrinsic kidney disease. While some of these anomalies are partially due to right ventricular insufficiency, recent data support a mechanistic link to the genetic and molecular events behind PAH pathogenesis. This review will serve as an introduction to the major systemic findings in PAH and the evidence that supports a common mechanistic link with PAH pathophysiology. In addition, we will discuss recent studies describing morphological changes in systemic vessels and the possible role of bronchopulmonary anastomoses in the development of plexogenic arteriopathy.

译文

肺动脉高压(pah)是一种以肺动脉进行性丢失和重塑导致右心衰竭和死亡为特征的疾病。直到最近,多环芳烃还被认为是一种限制肺循环的疾病。然而,越来越多的证据表明多环芳烃患者也表现出系统性血管功能障碍,表现为肱动脉血流介导的舒张功能受损、脑血流异常、骨骼肌病和固有性肾病。虽然其中一些异常部分是由于右心室功能不全所致,但最近的数据支持pah发病机制背后的遗传和分子事件的机制联系。本文将介绍多环芳烃的主要系统性发现和支持多环芳烃病理生理学共同机制联系的证据。此外,我们将讨论最近的研究,描述系统血管的形态学变化和支气管-肺吻合术在丛源性动脉病发展中可能的作用。