微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Synovial membrane
Synovial membrane

骨科

关键词骨科 临床研究术语 炎性关节炎

词汇介绍

拓展阅读

解析

synovial /saɪ'novɪəl/      

释义   adj. 滑液的;分泌滑液的 

例句   Primary synovial sarcoma of the kidney is a rare renal malignancy.  肾脏原发性滑液肉瘤是一种罕见的肾脏肿瘤。

 

membrane 英 /'membreɪn/  美 /'mɛmbren/      

释义   n. 膜;薄膜;羊皮纸

复数 membranes 

例句   Once the toxin perforates the host membrane, ions begin to leak out of the cell.  一旦毒素穿孔于宿主细胞膜,离子便开始从细胞中泄漏出去。


概述

研究表明,滑膜在炎性关节病( inflammatory joint disease,IJD)中起着重要作用,它既可以抑制炎症的产生,又可以在一定程度上导致骨关节炎、类风湿关节炎(rheumatoid arthritis, RA)、银屑病关节炎等的发生。 病因及病理机制关节滑膜具有分泌滑液、营养关节软骨、清除微小损伤或由细菌、病毒感染形成的碎片的作用,同时参与关节组织修复并维持关节腔稳态。正常滑膜主要由成纤维样滑膜细胞( fibroblast-like synoviocyt

SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma复制标题

滑膜肉瘤中YAP/TAZ信号SS18-SSX-Dependent

发表时间:2019-06-15

影响因子:8.9

作者: Ilka Isfort

期刊:Cli cancer Res

Synovial sarcoma (SySa) is an aggressive malignancy comprising approximately 2% of all sarcomas with a predominance in adolescents and young adults. Wide surgical resection, radiotherapy and chemotherapy with ifosfamide and doxorubicin represent established therapeutic options; however, prognosis in the metastatic situation is poor. Specific molecularly targeted therapeutic approaches are currently limited.The molecular hallmark of SySa is a pathognomonic reciprocal t(X;18) (p11; q11) translocation, leading to the fusion of SS18 (SYT) and one of the homologues SSX genes (most frequently SSX1 or SSX2, in rare cases SSX4), generating chimeric SS18-SSX fusion proteins. Although the SS18-SSX protein is known to play a crucial role in SySa tumorigenesis, its specific biological function and its mechanism of action remain to be elucidated. Neither SS18 and the SSX proteins, nor the chimeric SS18-SSX oncoproteins feature known DNA-binding motifs; however, they have been reported to contribute to the dysregulation of gene expression through association with SWI/SNF and Polycomb chromatin remodeling complexes.

译文

滑膜肉瘤(SySa)是一种侵袭性恶性肿瘤,约占所有肉瘤的2%,主要发生在青少年和年轻人中。广泛的手术切除,异环磷酰胺和阿霉素的放疗和化疗是已确立的治疗选择;但是,转移情况下的预后很差。目前,特定的分子靶向治疗方法受到限制。SySa的分子特征是可逆的t(X; 18)(p11; q11)易位,导致SS18(SYT)与SSX同源基因之一(最常见的是SSX1或SSX2,在极少数情况下为SSX4)融合。 ,生成嵌合的SS18-SSX融合蛋白。尽管已知SS18-SSX蛋白在SySa肿瘤发生中起关键作用,但其特定的生物学功能及其作用机制仍有待阐明。 SS18和SSX蛋白以及嵌合的SS18-SSX癌蛋白均不具有已知的DNA结合基序。然而,据报道它们通过与SWI / SNF和Polycomb染色质重塑复合体的结合而导致基因表达失调。