释义 adj. 滑液的；分泌滑液的
例句 Primary synovial sarcoma of the kidney is a rare renal malignancy. 肾脏原发性滑液肉瘤是一种罕见的肾脏肿瘤。
membrane 英 /'membreɪn/ 美 /'mɛmbren/
释义 n. 膜；薄膜；羊皮纸
例句 Once the toxin perforates the host membrane, ions begin to leak out of the cell. 一旦毒素穿孔于宿主细胞膜，离子便开始从细胞中泄漏出去。
作者： Ilka Isfort
期刊：Cli cancer Res
Synovial sarcoma (SySa) is an aggressive malignancy comprising approximately 2% of all sarcomas with a predominance in adolescents and young adults. Wide surgical resection, radiotherapy and chemotherapy with ifosfamide and doxorubicin represent established therapeutic options; however, prognosis in the metastatic situation is poor. Specific molecularly targeted therapeutic approaches are currently limited.The molecular hallmark of SySa is a pathognomonic reciprocal t(X;18) (p11; q11) translocation, leading to the fusion of SS18 (SYT) and one of the homologues SSX genes (most frequently SSX1 or SSX2, in rare cases SSX4), generating chimeric SS18-SSX fusion proteins. Although the SS18-SSX protein is known to play a crucial role in SySa tumorigenesis, its specific biological function and its mechanism of action remain to be elucidated. Neither SS18 and the SSX proteins, nor the chimeric SS18-SSX oncoproteins feature known DNA-binding motifs; however, they have been reported to contribute to the dysregulation of gene expression through association with SWI/SNF and Polycomb chromatin remodeling complexes.