摘要

The ability to effectively treat patients with rheumatoid arthritis (RA) has become increasingly feasible with the use of powerful treatment regimens early on in the disease. The use of such regimens has, however, created a pressing requirement for better prognostic markers to allow the targeting of these treatments to those most at need, hence minimizing expense and toxicity. As the synovial membrane has been ever more recognised as the primary pathogenetic site in RA its role as a prognostic indicator has been explored. As yet no reliable single prognostic marker has been identified. This article discusses the range of pathological variables already examined and those markers holding most potential.

译文

能有效治疗类风湿性关节炎 (RA) 已成为越来越多的使用功能强大的治疗方法的早期就。采用这种方案以来,不过,迫切需要改善预后标志物,针对这些疗法对那些最需要,从而最大限度地降低费用和毒性。如滑膜已越来越被认为主要发病部位在 RA 作为预后指标的探讨。迄今尚无可靠的单预后被确定。本文讨论了已经检查的病理变量的范围以及那些最有潜力的标记。

Synovial membrane

骨科 炎性关节炎 临床研究术语
概述  :  

研究表明,滑膜在炎性关节病( inflammatory joint disease,IJD)中起着重要作用,它既可以抑制炎症的产生,又可以在一定程度上导致骨关节炎、类风湿关节炎(rheumatoid arthritis, RA)、银屑病关节炎等的发生。 病因及病理机制关节滑膜具有分泌滑液、营养关节软骨、清除微小损伤或由细菌、病毒感染形成的碎片的作用,同时参与关节组织修复并维持关节腔稳态。正常滑膜主要由成纤维样滑膜细胞( fibroblast-like synoviocyt

synovial /saɪ'novɪəl/      

释义   adj. 滑液的;分泌滑液的 

例句   Primary synovial sarcoma of the kidney is a rare renal malignancy.  肾脏原发性滑液肉瘤是一种罕见的肾脏肿瘤。

 

membrane 英 /'membreɪn/  美 /'mɛmbren/      

释义   n. 膜;薄膜;羊皮纸

复数 membranes 

例句   Once the toxin perforates the host membrane, ions begin to leak out of the cell.  一旦毒素穿孔于宿主细胞膜,离子便开始从细胞中泄漏出去。


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