摘要

The ability to effectively treat patients with rheumatoid arthritis (RA) has become increasingly feasible with the use of powerful treatment regimens early on in the disease. The use of such regimens has, however, created a pressing requirement for better prognostic markers to allow the targeting of these treatments to those most at need, hence minimizing expense and toxicity. As the synovial membrane has been ever more recognised as the primary pathogenetic site in RA its role as a prognostic indicator has been explored. As yet no reliable single prognostic marker has been identified. This article discusses the range of pathological variables already examined and those markers holding most potential.

译文

能有效治疗类风湿性关节炎 (RA) 已成为越来越多的使用功能强大的治疗方法的早期就。采用这种方案以来，不过，迫切需要改善预后标志物，针对这些疗法对那些最需要，从而最大限度地降低费用和毒性。如滑膜已越来越被认为主要发病部位在 RA 作为预后指标的探讨。迄今尚无可靠的单预后被确定。本文讨论了已经检查的病理变量的范围以及那些最有潜力的标记。