Sciatica 英 /saɪ'ætɪkə/ 美 /saɪ'ætɪkə/
释义 n. [内科] 坐骨神经痛
例句 Sciatica is pain, weakness, numbness or tingling that can begin in the lower back and run down even to the toes. 坐骨神经痛是疼痛，乏力，麻木或刺痛，可以开始在腰部和运行下来甚至到了脚趾。
慢性坐骨神经痛的18F-FDG PET/MRI: 早期结果揭示脊柱和非脊柱异常
作者： Cipriano Peter W
期刊：J NUCL MED
18F-FDG PET/MRI is a novel diagnostic approach that can offer metabolic and structural examinations of painful lesions. Compared with separate acquisition with each modality, simultaneous acquisition with PET and MRI can greatly mitigate motion-induced misregistration. This advantage is significant for specifying pain sources because the common sources of sciatic pain, such as a herniated disk, degenerated facet joints, and impinged spinal nerves, are located very close to one another. The high sensitivity of 18F-FDG PET for metabolically hyperactive foci can be used to detect an abnormal increase in metabolism caused by painful inflammation.A recent PET imaging study demonstrated increased 18F-FDG uptake in injured nerves of rats as well as in denervated calf musculature of the affected limb. Unfortunately, the low spatial resolution and lack of tissue contrast of PET limit distinction among multiple possible pathologies for a detected lesion. The high-resolution anatomic views and superior soft-tissue contrast of MRI can help to resolve the anatomic ambiguity of PET. On the other hand, when multiple or subtle structural abnormalities are detected on MRI, the metabolic contrast on PET can highlight the pain-relevant inflammatory changes within the detected lesions.