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首页 > 医学词汇大全 > Avascular Necrosis
Avascular Necrosis

骨科

关键词骨科 临床研究术语 临床疾病

词汇介绍

拓展阅读

解析

Avascular /ei'væskjulə/ 

释义   adj. [医] 无血管的

例句   Direct complications of fractures include problems with bone union, avascular necrosis, and bone infection. 直接由骨折引起的并发症包括与骨连接、无血管性坏死和骨感染相关的问题。

 

Necrosis 英 /ne'krəʊsɪs/  美 /nɛ'krosɪs/

释义   n. 坏死;坏疽;骨疽

例句   Straight vertical incision along the contracture cord and the area of skin adhesion can prevent the skin necrosis. 在掌腱膜挛缩和粘连严重的部位按长轴作直切口可以防止创缘皮肤坏死。

概述

股骨头缺血坏死是由不同病因导致股骨头血液供应破坏而引起软骨下骨变性、坏死,继而造成股骨头塌陷,最终导致髋关节退行性破坏性改变。该病多发生于35-55岁的青壮年,若不及时治疗,70%患者股骨头将塌陷,约3-4年后需行全髋关节置换。通常认为激素和酒精的摄入是股骨头缺血坏死最常见的两大病因,约占股骨头缺血坏死病例的40%。病因及临床意义激素是股骨头缺血坏死最常见的危险因素之一,但多大剂量构成骨坏死的威胁尚存在争议。多变量分析表明大剂量使用激素是一个独立性危险因素,认为在2~3个月内使用强的松龙或其

Spontaneous healing of avascular necrosis of the femoral head in sickle cell disease复制标题

镰状细胞病股骨头缺血性坏死的自发愈合

发表时间:2019-03-18

影响因子:6.1

作者: Itzep N P

期刊:AM J HEMATOL

Sickle cell disease (SCD) is an inherited hemoglobinopathy that affects approximately 100, 000 Americans, and millions more world-wide. Hemoglobin S (HbS) is caused by a single point mutation on the beta globin gene, causing valine to be substituted for glutamic acid. HbS polymerizes when deoxygenated and deforms the red blood cell into a sickle or crescent shape. These sickled red cells cause vaso-occlusion, leading to interruption in blood flow and ischemia and clinical complications. When the bone is affected, there can be loss of the bony trabeculae, subchondral collapse, and joint destruction resulting in avascular necrosis (AVN), often affecting the femoral head. Clinical symptoms of femoral head AVN include pain, gait disturbance, and functional limitations. AVN therapies include observation, physical therapy, core decompression, and in severe late stages, total hip arthroplasty. The natural history of femoral head AVN has been described as one of progression to chronic skeletal and articular degenerative changes leading to decreased mobility, abnormal gait, and leg length discrepancies. However, much of these natural history studies were performed prior to widespread hydroxyurea (HU) use or MRI screening, which is able to diagnose the disease at earlier stages. Here we present a case series of patients diagnosed with femoral head AVN, some of whom exhibited radiographic improvement of their AVN with little or no interventions.

译文

镰状细胞病(SCD)是一种遗传性血红蛋白病,影响大约10万美国人,并影响全世界数百万人。血红蛋白S(HbS)由β珠蛋白基因上的单点突变引起,导致缬氨酸取代谷氨酸。 HbS在脱氧时聚合并使红细胞变形成镰状或新月形。这些镰状红细胞引起血管闭塞,导致血流中断,缺血和临床并发症。当骨骼受到影响时,可能会出现骨小梁损失,软骨下塌陷和关节破坏导致缺血性坏死(AVN),常常影响股骨头。股骨头AVN的临床症状包括疼痛,步态障碍和功能限制。 AVN疗法包括观察,物理治疗,核心减压,以及严重晚期,全髋关节置换术。股骨头AVN的自然史被描述为慢性骨骼和关节退行性变化的进展之一,导致活动减少,步态异常和腿长差异。然而,这些自然史研究中的大部分是在广泛使用羟基脲(HU)或MRI筛查之前进行的,其能够在早期诊断疾病。在这里,我们提出了一系列被诊断患有股骨头AVN的患者,其中一些患者在很少或没有干预的情况下表现出AVN的影像学改善。