释义 adj. [医] 无血管的
例句 Direct complications of fractures include problems with bone union, avascular necrosis, and bone infection. 直接由骨折引起的并发症包括与骨连接、无血管性坏死和骨感染相关的问题。
Necrosis 英 /ne'krəʊsɪs/ 美 /nɛ'krosɪs/
释义 n. 坏死；坏疽；骨疽
例句 Straight vertical incision along the contracture cord and the area of skin adhesion can prevent the skin necrosis. 在掌腱膜挛缩和粘连严重的部位按长轴作直切口可以防止创缘皮肤坏死。
作者： Itzep N P
期刊：AM J HEMATOL
Sickle cell disease (SCD) is an inherited hemoglobinopathy that affects approximately 100, 000 Americans, and millions more world-wide. Hemoglobin S (HbS) is caused by a single point mutation on the beta globin gene, causing valine to be substituted for glutamic acid. HbS polymerizes when deoxygenated and deforms the red blood cell into a sickle or crescent shape. These sickled red cells cause vaso-occlusion, leading to interruption in blood flow and ischemia and clinical complications. When the bone is affected, there can be loss of the bony trabeculae, subchondral collapse, and joint destruction resulting in avascular necrosis (AVN), often affecting the femoral head. Clinical symptoms of femoral head AVN include pain, gait disturbance, and functional limitations. AVN therapies include observation, physical therapy, core decompression, and in severe late stages, total hip arthroplasty. The natural history of femoral head AVN has been described as one of progression to chronic skeletal and articular degenerative changes leading to decreased mobility, abnormal gait, and leg length discrepancies. However, much of these natural history studies were performed prior to widespread hydroxyurea (HU) use or MRI screening, which is able to diagnose the disease at earlier stages. Here we present a case series of patients diagnosed with femoral head AVN, some of whom exhibited radiographic improvement of their AVN with little or no interventions.