Paget Disease 英 [ˈpædʒɪt diˈzi:z] 美 [ˈpædʒɪt dɪˈziz]
释义 n. [医] 畸形性骨炎，佩吉特病，乳头乳晕湿疹样癌
例句 Lytic lesion in previously sclerotic pagetoid bone is concerning for malignant degeneration. Sarcomatous transformation occurs in <1% of all patients with Paget disease.
成人Paget 's病的诊断和治疗: 临床指南
作者： Ralston S H
期刊：J Bone Miner Res
Paget’s disease of the bone is a nonmalignant skeletal disorder characterized by focal abnormalities in bone remodeling at one (monostotic) or more (polyostotic) skeletal sites. Almost any bone can be affected, but there is a predilection for the pelvis, spine, femur, tibia, and skull.The main risk factors for PDB include increasing age, male sex, and ethnic background. The risk of developing PDB increases with age, with an approximate doubling in incidence each decade after the age of 50 years. Paget’s is more common in males (1.4:1) and in certain ethnic groups. Whites are most commonly affected, and the disease has been estimated to affect about 1% of people over the age of 55 years in the United Kingdom. It is also common in other European countries such as France, Spain, and Italy and in people of European descent who have emigrated to other regions of the world, such as Australia, New Zealand, the United States of America, and Canada. Paget’s disease is rare in Scandinavian countries, the Indian subcontinent, and Asian countries. Archeological studies of skeletal remains suggest that these differences in prevalence could be consistent with PDB having arisen as the result of genetic mutations that predispose to the disease in people from North-West Europe many centuries ago, with spread to other regions of the world through emigration.