微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Paget Disease
Paget Disease

骨科

关键词骨科 疾病 骨代谢障碍性疾病

词汇介绍

拓展阅读

解析

Paget Disease 英 [ˈpædʒɪt diˈzi:z] 美 [ˈpædʒɪt dɪˈziz] 

释义   n. [医] 畸形性骨炎,佩吉特病,乳头乳晕湿疹样癌

例句   Lytic lesion in previously sclerotic pagetoid bone is concerning for malignant degeneration. Sarcomatous transformation occurs in <1% of all patients with Paget disease.

在硬化性病变中出现溶骨性改变为恶性变的征象,肉瘤样改变出现于小于1%的病例中。

概述

一、疾病概述或定义畸形性骨炎是一种病因不明的慢性骨代谢障碍性疾病,1877年由Paget首次报道并命名。该病的病因尚未完全明确,多数学者认为可能与慢性病毒感染及遗传因素有关。畸形性骨炎在我国的发病率较欧美国家低,90%的病例发生于40岁以上的患者,男性多于女性,男女比例为3:2。 二、病因及临床意义畸形性骨炎是一种慢性进行性骨代谢异常疾病,其发病原因涉及许多学说,如炎症、肿瘤、内分泌紊乱、自身免疫疾病、结缔组织代谢先天缺陷等,但病因仍不清楚,现在大多数学者认为是一种慢性病毒感染和遗传因

Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline复制标题

成人Paget 's病的诊断和治疗: 临床指南

发表时间:2019-04-16

影响因子:6.3

作者: Ralston S H

期刊:J Bone Miner Res

Paget’s disease of the bone is a nonmalignant skeletal disorder characterized by focal abnormalities in bone remodeling at one (monostotic) or more (polyostotic) skeletal sites. Almost any bone can be affected, but there is a predilection for the pelvis, spine, femur, tibia, and skull.The main risk factors for PDB include increasing age, male sex, and ethnic background. The risk of developing PDB increases with age, with an approximate doubling in incidence each decade after the age of 50 years. Paget’s is more common in males (1.4:1) and in certain ethnic groups. Whites are most commonly affected, and the disease has been estimated to affect about 1% of people over the age of 55 years in the United Kingdom. It is also common in other European countries such as France, Spain, and Italy and in people of European descent who have emigrated to other regions of the world, such as Australia, New Zealand, the United States of America, and Canada. Paget’s disease is rare in Scandinavian countries, the Indian subcontinent, and Asian countries. Archeological studies of skeletal remains suggest that these differences in prevalence could be consistent with PDB having arisen as the result of genetic mutations that predispose to the disease in people from North-West Europe many centuries ago, with spread to other regions of the world through emigration.

译文

佩吉特的骨骼疾病是一种非恶性骨骼疾病,其特征是在一个(单一的)或更多(多发性)骨骼部位的骨重建中的局灶性异常。几乎任何骨头都会受到影响,但骨盆,脊椎,股骨,胫骨和颅骨都有偏好。PDB的主要风险因素包括年龄增长,男性和种族背景。发生PDB的风险随着年龄的增长而增加,50岁后每十年发病率几乎翻倍。佩吉特在男性(1.4:1)和某些种族群体中更常见。白人最常受到影响,据估计,这种疾病影响了英国55岁以上人口的1%左右。在法国,西班牙和意大利等其他欧洲国家以及移民到世界其他地区的欧洲人后裔中也很常见,如澳大利亚,新西兰,美利坚合众国和加拿大。佩吉特病在斯堪的纳维亚国家,印度次大陆和亚洲国家很少见。对骨骼遗骸的考古研究表明,这些流行率的差异可能与PDB一致,这种PDB是由许多世纪以前西北欧人群中易患该病的基因突变引起的,并通过移民传播到世界其他地区。