微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Infectious Arthritis
Infectious Arthritis

骨科

关键词骨科 临床研究术语 关节炎

词汇介绍

拓展阅读

解析

Arthritis 英 /ɑː'θraɪtɪs/ 美 /ɑr'θraɪtɪs/

释义   n. [外科] 关节炎

例句   They have to cope with arthritis and the other physical difficulties of aging.

他们必须要对付关节炎和由于衰老而引起的其他病痛。

概述

一、疾病概述或定义 在全身各大关节中,膝关节最易发生化脓性关节炎。按照传统治疗方法,对于化脓性膝关节炎,经保守治疗如不能控制感染,则应行关节切开清创术,而后行持续性关节冲洗吸引。这种方法疗程长,效果不确定,膝关节病废的发生率较高。随着关节镜技术的应用,化脓性膝关节炎进行早期彻底的微创清创成为可能。 二、病因及病理机制 膝关节化脓性关节炎通常是灾难性的疾患,主要是因其感染难以控制,病程长。在感染过程中,脓细胞释放的溶酶体会对以关节软骨为主的组织结构造成破坏,在软骨表面

Use of a baseline risk score to identify the risk of serious infectious events in patients with rheumatoid arthritis during certolizumab pegol treatment复制标题

使用基线风险评分来确定类风湿性关节炎患者在certolizumab (pegol) 治疗期间发生严重感染事件的风险。

发表时间:2017-12-15

影响因子:4.1

作者: Curtis J R

期刊:Arthritis Res Ther

In addition, older age and specific comorbidities that are relatively prevalent in the RA population, such as diabetes mellitus or chronic obstructive pulmonary disease (COPD), have been associated with an increased risk of SIEs during anti-TNF therapy. Concomitant treatment with systemic glucocorticoids has also been linked to an increased susceptibility to infection. In clinical practice, physicians have to balance the benefits of the different available treatments against their overall risk, as well as the risks associated with the characteristics of each patient. This often involves the complex task of extrapolating data from study populations to the individual patient level. Infection risk scores, which summarize the relative contributions of various patient characteristics in a single composite measure, may help clinicians to anticipate the potential risk of SIEs in individual patients and make better-informed treatment decisions when balancing the expected therapeutic risks and benefits for an individual patient.

译文

此外,在RA人群中相对普遍的年龄较大和特定的合并症,例如糖尿病或慢性阻塞性肺病(COPD),与抗TNF治疗期间SIE的风险增加有关。全身性糖皮质激素的伴随治疗也与感染易感性增加有关。在临床实践中,医生必须平衡不同可用治疗的益处与其总体风险以及与每个患者的特征相关的风险。这通常涉及将研究人群的数据外推至个体患者水平的复杂任务。感染风险评分总结了单个综合测量中各种患者特征的相对贡献,可以帮助临床医生预测个体患者中SIE的潜在风险,并在平衡个体的预期治疗风险和益处时做出更明智的治疗决策。患者。