Sarcoma 英 [sɑː'kəʊmə] 美 [sɑr'komə]
释 义 n. [肿瘤] 肉瘤，恶性毒瘤
例 句 Tissue origin of parenchyma tissue sarcoma and sorts of malignancy lymphoma are nodus.
作者： Annemiek M. van Maldegem
Chondrosarcomas are a heterogeneous, diverse group of tumors that share at least the characteristic of chondroid matrix production. After osteosarcoma, it is the second most common primary bone tumor in adults and accounts for 20% of new primary bone cancer cases. Conventional central chondrosarcoma is the most common subtype, and the majority is of low histologic grade, which, to date, is the best prognostic indicator.1-3 Low-grade chondrosarcoma tumors rarely metastasize, grow slowly, and have a favorable prognosis after surgery; therefore, in the new World Health Organization classification of 2010, grade I chondrosarcomas are reclassified as atypical cartilaginous tumors. Approximately 10% of conventional central chondrosarcomas are histologically high grade (grade II or III) with a high risk for distant metastases and/or local recurrence and, thus, a poor prognosis after resection alone. In the last decades, there has been no significant improvement in the survival of patients with chondrosarcoma. The only treatment option with curative intent is surgical resection.4 However, for some locations in the body, such as the pel- vis or the skull, resection with a wide margin is difficult to achieve; therefore, local recurrence and metastatic disease are more common. Currently, it is not believed that the available systemic therapy options improve outcome, although randomized studies and large series have not been published. Therefore, we conducted this study to gain insight into the outcome and the effectiveness of systemic treatment for patients with advanced, unresectable conventional central chondrosarcoma.