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首页 > 医学词汇大全 > Osteochondrosarcoma
Osteochondrosarcoma

骨科

关键词骨科 疾病 临床疾病

词汇介绍

拓展阅读

解析

Sarcoma    [sɑː'kəʊmə] [sɑr'komə]

        n. [肿瘤] 肉瘤,恶性毒瘤

       Tissue origin of parenchyma tissue sarcoma and sorts of malignancy lymphoma are nodus.

软组织肉瘤的组织起源和淋巴瘤的分类是重点中的难点。

概述

一、疾病概述或定义软骨肉瘤是发生于软骨细胞或成软骨结缔组织的原始间充质细胞或软骨基质胚胎残迹的骨恶性肿瘤,肿瘤细胞只形成软骨样组织。可由原位的良性肿瘤,如内生性软骨瘤或滑膜软骨瘤恶变而来。它是继骨肉瘤之后第二高发的骨恶性肿瘤,中青年多见。不同部位、组织学分型的软骨肉瘤恶性程度不一,诊疗方法也不一样。 二、流行病学及临床特点1.软骨肉瘤发病率约占骨恶性肿瘤的 20%,分为原发性和继发性软骨肉瘤。2013年骨肿瘤新分类中,根据软骨肉瘤的恶性程度及细胞分化程度分为I ~ III级;按部位分为

Outcome of advanced, unresectable conventional central chondrosarcoma复制标题

晚期、不可切除的常规中央型软骨肉瘤的预后

发表时间:2014-10-15

影响因子:6.1

作者: Annemiek M. van Maldegem

期刊:Cancer

Chondrosarcomas are a heterogeneous, diverse group of tumors that share at least the characteristic of chondroid matrix production. After osteosarcoma, it is the second most common primary bone tumor in adults and accounts for 20% of new primary bone cancer cases. Conventional central chondrosarcoma is the most common subtype, and the majority is of low histologic grade, which, to date, is the best prognostic indicator.1-3 Low-grade chondrosarcoma tumors rarely metastasize, grow slowly, and have a favorable prognosis after surgery; therefore, in the new World Health Organization classification of 2010, grade I chondrosarcomas are reclassified as atypical cartilaginous tumors. Approximately 10% of conventional central chondrosarcomas are histologically high grade (grade II or III) with a high risk for distant metastases and/or local recurrence and, thus, a poor prognosis after resection alone. In the last decades, there has been no significant improvement in the survival of patients with chondrosarcoma. The only treatment option with curative intent is surgical resection.4 However, for some locations in the body, such as the pel- vis or the skull, resection with a wide margin is difficult to achieve; therefore, local recurrence and metastatic disease are more common. Currently, it is not believed that the available systemic therapy options improve outcome, although randomized studies and large series have not been published. Therefore, we conducted this study to gain insight into the outcome and the effectiveness of systemic treatment for patients with advanced, unresectable conventional central chondrosarcoma.

译文

软骨肉瘤是一组异质的,多样化的肿瘤,至少具有软骨样基质生成的特征。骨肉瘤后,它是成人中第二常见的原发性骨肿瘤,占新发原发性骨癌病例的20%。常规中央软骨肉瘤是最常见的亚型,并且大多数是低组织学分级,迄今为止,这是最好的预后指标.1-3低级软骨肉瘤肿瘤很少转移,生长缓慢,手术后预后良好;因此,在2010年新的世界卫生组织分类中,I级软骨肉瘤被重新分类为非典型软骨肿瘤。大约10%的常规中央软骨肉瘤是组织学上高级的(II级或III级),具有远处转移和/或局部复发的高风险,因此仅在切除后预后不良。在过去的几十年中,软骨肉瘤患者的存活率没有显着改善。治疗意图唯一的治疗选择是手术切除.4然而,对于身体的某些部位,如骨盆或颅骨,很难实现大范围的切除术;因此,局部复发和转移性疾病更常见。目前,尽管随机研究和大型系列尚未发表,但并不认为可用的全身治疗方案可改善预后。因此,我们进行了这项研究,以深入了解晚期,不可切除的常规中央软骨肉瘤患者的全身治疗结果和有效性。