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首页 > 医学词汇大全 > Gangrene
Gangrene

骨科

关键词骨科 疾病 厌氧菌感染

词汇介绍

拓展阅读

解析

Gangrene 英 [ˈɡæŋɡriːn] 美 [ˈɡæŋɡriːn]

释义   n. [外科]坏疽

vi. 生坏疽;腐败

vt. 使生坏疽

例句   When gangrene set in, his foot have to be amputate.

他的脚生了坏疽,必须截肢

概述

坏疽分类 1.干性坏疽:多见于四肢末端,原因有下肢动脉粥样硬化、血栓闭塞性脉管炎等;由于动脉受阻而静脉仍通畅,使坏死组织水分少,加之空气蒸发,使病变组织干燥,细菌不易繁殖,病变发展慢;2.湿性坏疽:常发生于肢体或与外界相通的脏器(肠、子宫、肺等)。因动脉闭塞而静脉回流又受阻,坏死组织水分多,适合腐败菌生长,局部肿胀,呈污黑色。腐败菌分解蛋白质,产生吲哚、粪臭素等,引起恶臭。与正常组织分界不清,全身中毒症状重;3.气性坏疽:湿性坏疽基础上,因深部肌肉的开放性创伤合并产气荚膜

Fournier's gangrene and sodium-glucose co-transporter-2 inhibitors: A meta-analysis of randomized controlled trials复制标题

Fournier 's坏疽和钠-葡萄糖co-transporter-2抑制剂: 随机对照试验的荟萃分析

发表时间:2019-10-21

影响因子:6.1

作者: G. Antonio Silverii

期刊:Diabetes Obes Metab

Fournier's gangrene (FG) is a rare, life-threatening necrotizing fasciitis of the perineum. The US Food and Drug Administration (FDA) released a Drug Safety Communication regarding the risk of FG associated with sodium-glucose co-transporter-2 inhibitors (SGLT2i), relying on the FDA Adverse Event Reporting System. To verify this association, we performed a meta-analysis of all randomized controlled trials enrolling patients with type 2 diabetes, comparing SGLT2i with placebo or different therapies, collecting cases of FG reported as a serious adverse event. Risk of abscess, cellulitis and erysipela were secondary outcomes. We retrieved 84 trials enrolling 42 415 patients in the SGLT2i group and 27 158 patients in comparator groups. No difference was observed between SGLT2i and comparators in the risk of FG (Mantel-Haenzel odds ratio [MH-OR] 0.41 [0.09, 1.82]), abscess (MH-OR 0.94 [0.54, 1.65]), cellulitis (MH-OR 0.90 [0.71, 1.13] or erysipela (MH-OR 0.89 [0.45, 1.77]). The number of events was small, leading to a wide confidence interval that does not allow ruling out an increase in FG or skin and subcutaneous tissue infections.

译文

弗尼尔氏坏疽(FG)是一种罕见的会阴坏死性会阴筋膜炎。美国食品药品监督管理局(FDA)依靠FDA不良事件报告系统发布了有关与钠-葡萄糖共转运蛋白2抑制剂(SGLT2i)相关的FG风险的《药物安全通讯》。为了证实这种关联,我们对所有纳入2型糖尿病患者的随机对照试验进行了荟萃分析,将SGLT2i与安慰剂或不同疗法进行了比较,收集了报告为严重不良事件的FG病例。次要结果是脓肿,蜂窝织炎和丹毒的风险。我们检索了84个试验,其中SGLT2i组为42 415位患者,而比较组为27 158位患者。 SGLT2i与比较者之间在发生FG(Mantel-Haenzel比值比[MH-OR] 0.41 [0.09,1.82]),脓肿(MH-OR 0.94 [0.54,1.65]),蜂窝组织炎(MH-OR 0.90 [0.71,1.13]或丹毒(MH-OR 0.89 [0.45,1.77])。事件的数量少,导致较大的置信区间,不能排除FG或皮肤和皮下组织感染的增加。